Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Preventive Medicine Reports, 2020 Ethnic South Asian Americans (SAAs) have the highest relative risk of type 2 diabetes mellitus (T2DM) in the United States (US). Culturally tailored lifestyle interventions have the potential to promote South Asian diabetes prevention; however, the ...
Shahmir H. Ali +4 more
doaj
Weighing Physical Activity: The Impact of a Family-Based Group Lifestyle Intervention for Pediatric Obesity on Participants' Physical Activity [PDF]
, 2014 Jason Van Allen +3 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Comparing Traditional and Integrative Learning Methods in Organizational Training Programs [PDF]
, 1991 Previous research and anecdotal reports have suggested that when certain teaching approaches are utilized, students not only learn more, but also experience greater satisfaction with the training process.
Bretz, Robert D. , Jr. +1 more
core +1 more source
The Effectiveness of a Community-Based Mind Body Group Intervention for Depression & Anxiety: A Pilot Study [PDF]
, 2014 John W. Denninger +11 more
openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Are the group-based interventions improving the functional exercise capacity and quality of life of frail subjects with chronic heart failure? [PDF]
J Frailty Sarcopenia Falls, 2020 Papathanasiou JV.
europepmc +1 more source
Evidence-based preventive intervention for preadolescent aggressive children: One-year outcomes following randomization to group versus individual delivery. [PDF]
, 2015 John E. Lochman +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source