Results 81 to 90 of about 6,035,079 (297)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Intervensi Guru dalam Mengajarkan Daily Living Skills pada Anak Down Syndrome

Al-Athfal: Jurnal Pendidikan Anak, 2020
Daily living skills are an ability in someone in the field of independence in the form of daily activities. Daily living skills must be instilled early on. However, children with down syndrome must have specialized interventions so that children's living
Qonitah Faizatul Fitriyah
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mobile phone text messaging and app-based interventions for smoking cessation.

Cochrane Database of Systematic Reviews, 2019
BACKGROUND Mobile phone-based smoking cessation support (mCessation) offers the opportunity to provide behavioural support to those who cannot or do not want face-to-face support. In addition, mCessation can be automated and therefore provided affordably
R. Whittaker, H. McRobbie, C. Bullen, A. Rodgers, Yulong Gu, Rosie Dobson   +5 more
semanticscholar   +1 more source

Replicating group‐based education interventions for the management of type 2 diabetes: a review of intervention reporting [PDF]

Diabetic Medicine, 2019
AbstractAimsTo assess the completeness of reporting of group‐based education interventions for the management of type 2 diabetes.MethodsA previous systematic review of group‐based education programmes for adults with type 2 diabetes identified eligible intervention studies.
K. Odgers‐Jewell, L. E. Ball, D. P. Reidlinger, E. A. Isenring, R. Thomas, J. T. Kelly   +5 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparison of Instructor-Based and Parent-Based Interventions on Motor Development in Children with Developmental Coordination Disorder [PDF]

رشد و یادگیری حرکتی ورزشی, 2018
The purpose of this study was to compare instructor-based and parent-based interventions on motor development in 7 to 10 years old children with developmental coordination disorder.
Shima Abdolrahman Chapari, Mohammad Vaez Mousavi, Ali Kashi   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Implementation outcomes of the waves for change community-based task-shared prevention intervention for adolescent mental health in South Africa

Cambridge Prisms: Global Mental Health
Adolescents face increased vulnerability to mental health conditions, particularly when exposed to multidimensional poverty and trauma and pronounced treatment gaps.
Thandi Davies, Jamie Marshall, Nicola van der Merwe, Paula Yarrow, Tim Conibear, Crick Lund   +5 more
doaj   +1 more source

Effectiveness of online mindfulness-based interventions in improving mental health: A review and meta-analysis of randomised controlled trials.

Clinical Psychology Review, 2016
Mindfulness-based interventions (MBIs) are increasingly being delivered through the Internet. Whereas numerous meta-analyses have investigated the effectiveness of face-to-face MBIs in the context of mental health and well-being, thus far a quantitative ...
M.P.J. Spijkerman, Wendy T. M. Pots, E. Bohlmeijer   +2 more
semanticscholar   +1 more source