Results 181 to 190 of about 41,735,200 (392)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Rare Group A Rotavirus P[9]G3 Isolated in Nara Prefecture, Japan

, 2006
Yumiko Inoue, Yoshiteru Kitahori
openalex   +2 more sources

The form of the solution of the Cauchy Problem over a group [PDF]

, 1960
Robert D. Edwards
openalex   +1 more source

Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure. [PDF]

Asia Pac J Clin Nutr
Song S, Du H, Lu X, Luo B, Li Z.
europepmc   +1 more source

The Ripple Effect: Emotional Contagion and its Influence on Group Behavior

, 2002
Sigal G. Barsade
semanticscholar   +1 more source

Expression analysis of E-cad and vascular endothelial growth factor in triple-negative breast cancer patients of different ethnic groups in western China

, 2017
Weihua Jiang, Yongtao Li, Jianghua Ou, Xiaowen Wang, Chenguang Zhang, Lina Yi, Laiti Xue, Mingshuai Zhang   +7 more
openalex   +1 more source

Regional North American Annual Meeting of the World Federation of Neurology – Research Group on Neuroepidemiology. Boston, Mass., May 4, 2007 [PDF]

, 2007
Sarah L. Vowler, Li Li, Oliver Redmayne, Robert A. Fulcher, Douglas Dulli, Edgar A. Samaniego, B.M. van Gelder, M.A.R. Tijhuis, S. Kalmijn, S. Giampaoli, D. Kromhout, Ophélia Godin, Carole Dufouil, Karen Ritchie, Jean-François Dartigues, Christophe Tzourio, Karine Pérès, Sylvaine Artero, Annick Alpérovitch, Lars Frost, Ljubica Vukelic Andersen, John Godtfredsen, Leif Spange Mortensen, Cristina Cusi, Teresa Anna Cantisani, Maria Grazia Celani, Barbara Incorvaia, Enrico Righetti, Livia Candelise, Cosimo Maggiore, Laura Locatelli, Fabio Chiodo Grandi, Gilberto Pizzolato, Layla Jader, Phyo K. Myint   +34 more
openalex   +1 more source