Results 201 to 210 of about 359,357 (309)

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Routine testing for group B streptococcus in pregnancy: protocol for a UK cluster randomised trial (GBS3). [PDF]

BMJ Open
Daniels J, Walker K, Bradshaw L, Dorling J, Ojha S, Gray J, Thornton J, Plumb J, Petrou S, Madan J, Achana F, Ayers S, Constantinou G, Mitchell EJ, Downe S, Grace N, Plachcinski R, Cooper T, Moore S, Jones AM, Harrison E, Brooks J, Barker-Williams K, Hollands H, Mcleavey SK, Willson S, Webster S, Carpenter J, Hyslop-Peart M, Wills L, Haines R, Haydock R, Sadiq S, Fiaschi L, Evans L, Ogollah R, Seale J, Spas S, Huang L, Moody S, Abramson J, GBS 3 Collaborative Group.   +41 more
europepmc   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Prospective study of peripartum group B streptococcus colonization in Japanese mothers and neonates - ERRATUM. [PDF]

Epidemiol Infect
Yoshida E, Takeda J, Maruyama Y, Suga N, Takeda S, Arai H, Itakura A, Makino S.   +7 more
europepmc   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, EarlyView.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Antidiabetic Potential of Ligands from NEIST_PMIB_06, Bacterium Associated with Hawaijar (Fermented Soy Food): Insight from in Vitro and in Silico Studies

ChemFoodChem, EarlyView.
ABSTRACT In this study, a bacterium (NEIST_PMIB_06) was isolated from Hawaijar, a fermented soy food from Manipur, Northeast India. The bacterium was inoculated and incubated to isolate bioactive compounds. Liquid‐liquid extraction was performed to obtain extracts (cell‐free and cell‐based), and their efficacy was evaluated.
A Ibeyaima, Hiranmoy Barman, Prasenjit Manna   +2 more
wiley   +1 more source

Pharmacokinetics of Intrapartum Benzylpenicillin: Insights Into Candidate Regimens to Prevent Early Onset Neonatal Group B Streptococcus Disease. [PDF]

CPT Pharmacometrics Syst Pharmacol
Obura B, Unsworth J, Jimenez-Valverde A, Waitt C, Das S, Hope W, Navaratnam K.   +6 more
europepmc   +1 more source

Comparison of five genotypic techniques for identification of optochin-resistant pneumococcus-like isolates [PDF]

, 2003
Claeys, Geert, De Baere, Thierry, De Ganck, Catharine Clara, KAIJALAINEN, T, Van Simaey, Leen, Vaneechoutte, Mario, Verhelst, Rita, Verschraegen, Gerda   +7 more
core  

Two‐Step Synthesis of a Chiral Fluorinated Alcohol With Silica‐Supported Enzyme RrADH in Batch and Continuous Flow Mode

Chemistry – A European Journal, EarlyView.
A two‐step process was transferred from batch to flow mode for the synthesis of (R)‐2‐fluoro‐1‐phenylethanol as a benchmark, consisting of a decarboxylative fluorination in aqueous media, followed by an enantioselective biocatalytic reduction of the prochiral intermediate with RrADH immobilized on silica supraparticles.
Egzon Cermjani, Greta Nölke, Stefano Di Fiore, Christoph Deckers, Doris Hanselmann, Bettina Herbig, Susanne Wintzheimer, Thomas H. Rehm   +7 more
wiley   +1 more source