Results 211 to 220 of about 244,980 (306)

A dendrimer enhanced CRISPR/Cas12a performance for the evaluation of acidogenic capacity in cariogenic bacteria

Interdisciplinary Medicine, EarlyView.
A CRISPR/Cas12a‐powered dendritic DNA nanostructure is assembled to create confined enzymatic microdomains, enabling ultrasensitive detection. Integrated into a paper‐based origami biosensor, it allows equipment‐free on‐site quantification of acidogenic pathogens for the early diagnosis of dental caries.
Yuan Zhang, Yining Zhao, Murtaza Sayed, Feng Chen, Juan Zhang   +4 more
wiley   +1 more source

Clinical characteristics and risk factors for imaging abnormalities in pediatric Group B Streptococcus meningitis: a multicenter study. [PDF]

Transl Pediatr
Liu X, Xu H, Liu G, Yu H, Zheng G, Xu Z, Tian J, Liu J, Wang D, Li H, Shan Q, Shu M, Chen Y.   +12 more
europepmc   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Group B <italic>Streptococcus</italic> and Vaginal Microbiome Dynamics in Pregnancy. [PDF]

Med Princ Pract
Dilrukshi N, Kottahachchi J, Dissanayake T, Muneeswaran K, Fernando N.   +4 more
europepmc   +1 more source

Ordered assembly of Cas12a for better performance of CRISPR/Cas system with application to the diagnosis of dental caries

Interdisciplinary Medicine, EarlyView.
Here, we present a tetrahedral DNA framework (TDF)‐mediated Cas12a ordered assembly strategy. TDFs arrange CRISPR/Cas12a into ordered structures controllably, enhancing catalytic efficiency through localized Cas12a hotspots while maintaining spatial intervals to facilitate substrate diffusion.
Yining Zhao, Panpan Qiao, Yujing Zeng, Murtaza Sayed, Qin Mi, Juan Zhang, Genxi Li   +6 more
wiley   +1 more source

The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection. [PDF]

PLoS Pathog
Brokaw A, Wallen G, Orvis A, Kwon HJ, Seepersaud R, Nguyen S, Sharma K, Coleman M, Quach P, Twentyman J, Vornhagen J, Jones LA, Lin C, Gafken PR, Rajagopal L.   +14 more
europepmc   +1 more source

Duplex Recombinase Polymerase Amplification‐Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a pair of duplex RPA‐LFA assays for the simultaneous detection of critical resistance genes, blaCTX‐M/mcr‐1 and blaoxa‐48‐like/blaNDM, from hemoculture samples. Under optimized conditions, duplex RPA was performed at 37°C–38°C for 25 min, followed by LFA for 10–15 min.
Variya Nemidkanam, Pattamaporn Deechart, Nuntaree Chaichanawongsaroj   +2 more
wiley   +1 more source

Beyond Colonization: An Atypical Presentation of Maternal Group B Streptococcus Infection. [PDF]

Cureus
Kaki S, Natemeier M, Clark M, Jurecki M.
europepmc   +1 more source

Gut Microbiota: A Reservoir for Extraintestinal Bacterial Infections in Febrile Term Infants

iLABMED, EarlyView.
Ran Wang, Renqiang Yu
wiley   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source