Results 51 to 60 of about 239,283 (241)

Is Penicillin plus Gentamicin Synergistic against Clinical Group B Streptococcus isolates?: A in-vitro Study.

Frontiers in Microbiology, 2016
Group B Streptococcus (GBS) is increasingly causing invasive infections in nonpregnant adults. Elderly patients and those with comorbidities are at increased risk.
Corinne Ruppen, Agnese Lupo, Laurent Decosterd, Parham Sendi   +3 more
doaj   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Progress in the prevention of group B Streptococcus

Vaccine: X
Group B Streptococcus (GBS) is a significant bacterial pathogen that poses substantial health risks, particularly among neonates and pregnant women. It is responsible for a range of severe infections, including sepsis, pneumonia, and meningitis, which ...
Shuang Gao, Xiaona Wang, Xiaojuan Sun, Kangyi Li   +3 more
doaj   +1 more source

Progress toward a group B streptococcal vaccine

Human Vaccines & Immunotherapeutics, 2018
Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide.
Joon Young Song, Jae Hyang Lim, Sangyong Lim, Zhi Yong, Ho Seong Seo   +4 more
doaj   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

GROUP B STREPTOCOCCUS NEONATAL MENINGITIS—LESS COMMON CAUSE OF NEONATAL MENINGITIS IN PAKISTAN AND DISPARITY BETWEEN CSF CULTURE AND OTHER PARAMETERS

Pakistan Armed Forces Medical Journal, 2015
Neonatal bacterial meningitis is a devastating illness with significant mortality and morbidity. Incidence and etiology of neonatal bacterial sepsis and meningitis varies among developed and developing countries.
Shabbir Hussain, Tariq Mahmood Ahmad, Saba Haider Tarar   +2 more
doaj   +2 more sources

Phenotypical characteristics of group B streptococcus in parturients

Brazilian Journal of Infectious Diseases
Colonization by Group B Streptococcus (GBS) is highly prevalent among pregnant women, with prevalence rates ranging between 4% and 30%. The infection may be transmitted vertically and may result in serious neonatal consequences.
Jose Antonio Simoes, Valeria Moraes Neder Alves, Sergio Eduardo Longo Fracalanzza, Rodrigo Pauperio Soares de Camargo, Lenir Mathias, Helaine Maria Besteti Pires Milanez, Eliane Melo Brolazo   +6 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source