Results 51 to 60 of about 36,289 (270)

The classification of flag-transitive Steiner 3-designs

open access: yes, 2004
We solve the long-standing open problem of classifying all 3-(v,k,1) designs with a flag-transitive group of automorphisms (cf. A. Delandtsheer, Geom. Dedicata 41 (1992), p. 147; and in: "Handbook of Incidence Geometry", ed. by F.
Huber, Michael
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Combinatorial aspects of covering arrays

open access: yesLe Matematiche, 2004
Covering arrays generalize orthogonal arrays by requiring that t -tuples be covered, but not requiring that the appearance of t -tuples be balanced.Their uses in screening experiments has found application in software testing, hardware testing, and a ...
Charles J. Colbourn
doaj  

DeMAID: A Design Manager's Aide for Intelligent Decomposition user's guide [PDF]

open access: yes
A design problem is viewed as a complex system divisible into modules. Before the design of a complex system can begin, the couplings among modules and the presence of iterative loops is determined.
Rogers, James L.
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An intelligent advisor for the design manager [PDF]

open access: yes
A design problem is viewed as a complex system divisible into modules. Before the design of a complex system can begin, much time and money are spent in determining the couplings among modules and the presence of iterative loops.
Padula, Sharon L., Rogers, James L.
core   +1 more source

HFR Code: A Flexible Replication Scheme for Cloud Storage Systems

open access: yes, 2015
Fractional repetition (FR) codes are a family of repair-efficient storage codes that provide exact and uncoded node repair at the minimum bandwidth regenerating point.
Li, Hui   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Hewitt-Marczewski-Pondiczery type theorem for abelian groups and Markov's potential density

open access: yes, 2009
For an uncountable cardinal \tau and a subset S of an abelian group G, the following conditions are equivalent: (i) |{ns:s\in S}|\ge \tau for all integers n\ge 1; (ii) there exists a group homomorphism \pi:G\to T^{2^\tau} such that \pi(S) is dense in T ...
Dikranjan, Dikran, Shakhmatov, Dmitri
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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