Results 111 to 120 of about 3,569,422 (339)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Entanglement and correlations in the continuous multi-scale entanglement renormalization ansatz
Journal of High Energy Physics, 2017 We investigate the entanglement structure of the continuous multi-scale entanglement renormalization ansatz (cMERA) [Haegeman et al., Phys. Rev. Lett. 110 (2013) 100402] for ground states of quantum field theories (QFTs).
Adrián Franco-Rubio, Guifré Vidal
doaj +1 more source
Emergent matter from 3d generalised group field theories
, 2010 We identify classical solutions of a generalised group field theory model in 3 dimensions, and study the corresponding perturbations, deriving their effective dynamics. We discuss their interpretation as emergent matter fields. This allows us, on the one
Di Mare, Alessandro, Oriti, Daniele
core +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Nuclear Physics BThe observation that spacetime and quantum fields on it have to be dynamically produced in any theory of quantum gravity implies that quantum gravity should be defined on the configuration space of fields rather than spacetime. Such a theory is described
Mir Faizal +2 more
doaj +1 more source
Scalar CFTs and their large N limits
Journal of High Energy Physics, 2018 We study scalar conformal field theories whose large N spectrum is fixed by the operator dimensions of either the Ising model or the Lee-Yang edge singularity. Using the numerical bootstrap to study CFTs with S N ⊗ Z 2 symmetry, we find a series of kinks
Junchen Rong, Ning Su
doaj +1 more source
Orbifold Construction for Topological Field Theories
, 2018 An equivariant topological field theory is defined on a cobordism category of manifolds with principal fiber bundles for a fixed (finite) structure group. We provide a geometric construction which for any given morphism $G \to H$ of finite groups assigns
Schweigert, Christoph, Woike, Lukas
core +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Seeking fixed points in multiple coupling scalar theories in the ε expansion
Journal of High Energy Physics, 2018 Fixed points for scalar theories in 4 − ε, 6 − ε and 3 − ε dimensions are discussed. It is shown how a large range of known fixed points for the four dimensional case can be obtained by using a general framework with two couplings.
Hugh Osborn, Andreas Stergiou
doaj +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source