Results 101 to 110 of about 815,202 (268)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Guidance for Group Discussionいじめ,不登校,学級崩壊など学校現場での問題が絶えない現在,それらに対応できる教師を求めて,教員採用試験のポイントが筆記試験重視から人物重視へと移ってきている。筆記試験だけでなく,小論文,グループ・ディスカッション,個人面接などを通して,さまざまな角度から受験者を評価し,採用を決めようとする都道府県が増えているようである。受験者は採用試験に向けて周到な準備が必要であるが,グループ・ディスカッションは一人では十分な準備ができない点でネックとなりうる。相原は2008年度から茨城大学人文学部の「英語科教育法II」で,グループ・ディスカッションに向けての指導を行っている。本論では,2009年度の指導を取り上げ,グループ・ディスカッションでは何が求められるかを示した。 6 ...
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Indonesian Journal of Guidance and Counseling: Theory and Application, 2013 Tujuan penelitian ini adalah untuk meningkatkan keaktifan siswa dalam diskusi kelompok pada siswa kelas VIIIE melalui layanan bimbingan kelompok. Penelitian ini termasuk dalam jenis penelitian eksperimen.
Mera Rizkina +2 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Pengaruh Layanan Bimbingan Kelompok Terhadap Perilaku Prososial
Indonesian Journal of Guidance and Counseling: Theory and Application, 2017 Prosocial behavior is the behavior of mutual help without expecting anything in return. There are students who already have prosocial behavior, but there are also students who lack prosocial behavior.
Anik Mahtun Fajar Rini +1 more
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source