Results 91 to 100 of about 62,692 (225)

Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [PDF]

, 2008
Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri, Sami, Jeon, Mili, Nguyen, Huong, Zinn, Kai   +3 more
core   +4 more sources

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Nucleic acid enzymes for cleaving DNA [PDF]

, 2001
The present invention discloses nucleic acid enzymes capable of cleaving single-stranded DNA in a site specific ...
Joyce, Gerald F.
core   +1 more source

Confirmation of BIK and SAMHD1 as Prostate Cancer Susceptibility Genes

The Prostate, EarlyView.
ABSTRACT Background To independently assess data for recently reported genes—BIK, SAMHD1, FAM111A, and AOX1—in which rare variants have been associated with prostate cancer (PCa) risk and aggressiveness. Methods The study included 4448 PCa cases from Johns Hopkins School of Medicine and 103,221 population‐based controls from the Genome Aggregation ...
Christian P. Pavlovich, Jun Wei, Marta Gielzak, Zhuqing Shi, Huy Tran, Annabelle Ashworth, S. Lilly Zheng, Patrick C. Walsh, Jun Luo, Brian T. Helfand, William B. Isaacs, Jianfeng Xu   +11 more
wiley   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

The RNA‐Puzzles Assessments of RNA‐Only Targets in CASP16

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT RNA‐Puzzles was launched in 2011 as a collaborative effort dedicated to advancing and improving RNA 3D structure prediction. The automatic evaluation protocols for comparisons between prediction and experiment developed within RNA‐Puzzles are applied to the 2024 CASP16 competition.
Eric Westhof, Hao Sun, Fan Bu, Zhichao Miao   +3 more
wiley   +1 more source

Control of two sucking insect pests, a whitefly (Bemisia tabaci) and a thrips (Frankliniella occidentalis), infesting hot peppers by spraying LDH‐formulated dsRNA

Pest Management Science, EarlyView.
A vacuolar type ATPase subunit B (vATPase‐B) gene is identified and expressed in the midgut of Bemisia tabaci and Frankliniella occidentalis. The double‐stranded RNA (dsRNA) specific to vATPase‐B was expressed in hot peppers by virus‐induced gene silencing (VIGS) and killed both whitefly and thrips.
Falguni Khan, Tae‐Geun Song, Yonggyun Kim   +2 more
wiley   +1 more source

The structural stabilization of the κ three-way junction by Mg(II) represents the first step in the folding of a group II intron [PDF]

, 2017
Folding of group II introns is characterized by a first slow compaction of domain 1 (D1) followed by the rapid docking of other domains to this scaffold. D1 compaction initiates in a small subregion encompassing the κ and ζ elements.
Donghi, Daniela, Finazzo, Cinzia, Knobloch, Bernd, Pechlaner, Maria, Sigel, Roland K. O.   +4 more
core  

An epigenomic threshold hypothesis for integrating dynamic environmental signals into functional models of developmental polyphenisms

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source