Results 101 to 110 of about 62,692 (225)

Telomerase modRNA Offers a Novel RNA‐Based Approach to Treat Human Pulmonary Fibrosis

Aging Cell, EarlyView.
Recombinant linear and circular hTERT mRNA restore telomerase activity in primary ATII cells and ex vivo lung tissue from patients with pulmonary fibrosis, leading to telomere elongation, reduced DNA damage, and decreased senescence and fibrosis markers.
Jia Li Ye, Klaudia Grieger, Dongchao Lu, Christina Brandenberger, Malte Juchem, Maria Jordan, Lea Oehlsen, Patrick Zardo, Christopher Werlein, Christina Hesse, Katherina Sewald, Sandy Tretbar, Thomas Thum, Shambhabi Chatterjee, Christian Bär   +14 more
wiley   +1 more source

T. thermophila group I introns that cleave amide bonds [PDF]

, 1997
The present invention relates to nucleic acid enzymes or enzymatic RNA molecules that are capable of cleaving a variety of bonds, including phosphodiester bonds and amide bonds, in a variety of substrates.
Joyce, Gerald F.
core   +1 more source

Mapping VEXAS‐associated and rare UBA1 variants in the United Kingdom: Insights from patient cohorts and the general population

British Journal of Haematology, EarlyView.
VEXAS syndrome is a late‐onset inflammatory disorder with rheumatological and haematological features. Epidemiological studies of VEXAS syndrome so far have been limited. Analysis of various UK cohorts estimates the incidence of VEXAS to be 1.51/100 000, or 171 new cases in the population of men over the age of 50 who are being investigated for myeloid
Ana Martinez Rodriguez, Leon Chang, Dorota Rowczenio, Alexandra Smith, Ebun Omoyinmi, James A. Poulter, Andrew McGregor, Sebastian Francis, Roochi Trikha, Adam Al‐Hakim, Kar Lok Kong, David G. Kent, Helen Lachmann, Austin Kulasekararaj, Catherine Cargo, Sinisa Savic   +15 more
wiley   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Functional characterization of hexokinases in the moss Physcomitrella patens [PDF]

, 2005
Carbohydrates are important nutrients and structural components in all living organisms. In plants they affect the developmental and metabolic processes throughout the plant life cycle.
Olsson, Tina
core  

Conserved spatial patterning of gene expression in independent lineages of C4 plants

New Phytologist, EarlyView.
Summary C4 photosynthesis enhances carbon fixation efficiency by reducing photorespiration through the use of an oxygen‐insensitive carboxylase and spatial separation of photosynthesis between mesophyll and bundle sheath cells. The C4 pathway has evolved independently in > 60 plant lineages, but molecular mechanisms underpinning this convergence remain
Tianshu Sun, Venkata Suresh Bonthala, Benjamin Stich, Leonie H. Luginbuehl, Julian M. Hibberd   +4 more
wiley   +1 more source

DNA methylation contributes to plant acclimation to naturally fluctuating light

New Phytologist, EarlyView.
Summary Plants in the natural environment experience continuous dynamic changes in light intensity. Here, we exposed Arabidopsis thaliana plants to naturally fluctuating light (FL) regimes alongside traditional square light (SQ) regimes such as those often found in control environment growth chambers.
Robyn A. Emmerson, Philip Davey, Mouesanao Kandjoze, Ulrike Bechtold, Nicolae Radu Zabet, Tracy Lawson   +5 more
wiley   +1 more source

Aquilaria sinensis MYB‐Like Transcription Factor AsMYB1 Promotes 2‐(2‐Phenylethyl)Chromone Biosynthesis Through Interacting With 14‐3‐3 Family Protein AsGRF1

Plant Biotechnology Journal, EarlyView.
ABSTRACT 2‐(2‐Phenylethyl)chromones (PECs) are the primary constituents of agarwood, a valuable aromatic resin widely used in traditional oriental medicine and incense production, exhibiting diverse pharmacological activities. While we have previously reported a polyketide synthase (AsPECPS) playing a crucial role in the biosynthesis of PECs in ...
Xinyu Mi, Fanyuan Guan, Yuyan Zheng, Jing Fan, Hailing Qiu, Bowen Gao, Xiao Liu, Juan Wang, Jun Li, Shepo Shi, Xiaohui Wang, Pengfei Tu   +11 more
wiley   +1 more source

The Spliceosomal Protein Prp8 Stabilizes A Compact Conformation Of The U2-U6 Complex [PDF]

, 2012
The spliceosome is a large, RNA-protein complex that catalyzes pre-mRNA splicing during mRNA maturation. The RNA components (small nuclear RNA; snRNAs) of the spliceosome have been well studied and are believed to be involved in the splicing catalysis ...
Subasinghe, Subasinghe Appuhamilage Lemintha Imali
core   +1 more source