Results 111 to 120 of about 49,487 (207)

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

The Immunological Consequences of Clonal Hematopoiesis in Heart Failure

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Inflammation is increasingly recognized as a central driver of heart failure (HF), particularly in older adults, yet the underlying immune mechanisms remain diverse and incompletely understood. Clonal hematopoiesis (CH), defined by the expansion of somatically mutated hematopoietic clones, has emerged as a risk factor for the development of ...
Megan A. Evans, Kenneth Walsh
wiley   +1 more source

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source

Comprehensive Genome‐Wide Identification and Expression Analysis of the N6‐Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Exogenous melatonin has emerged as a pivotal multifunctional signaling molecule, recognized for its critical role in enhancing stress tolerance and improving crop productivity. N6‐methyladenosine (m6A) is the most prevalent internal modification found in eukaryotic mRNA and plays a crucial role in regulating plant growth, development, and ...
Hira Khanzada, Ghulam Mustafa Wassan, Ping Wang, Saba Khanzada, Xiaoning Wang, Zhihui Xia   +5 more
wiley   +1 more source

Conserved spatial patterning of gene expression in independent lineages of C4 plants

New Phytologist, Volume 249, Issue 1, Page 24-38, January 2026.
Summary C4 photosynthesis enhances carbon fixation efficiency by reducing photorespiration through the use of an oxygen‐insensitive carboxylase and spatial separation of photosynthesis between mesophyll and bundle sheath cells. The C4 pathway has evolved independently in > 60 plant lineages, but molecular mechanisms underpinning this convergence remain
Tianshu Sun, Venkata Suresh Bonthala, Benjamin Stich, Leonie H. Luginbuehl, Julian M. Hibberd   +4 more
wiley   +1 more source

Assessment of genetically modified soybean MON 94313 (application GMFF‐2022‐6595)

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract Genetically modified soybean MON 94313 was developed to confer tolerance to dicamba, glufosinate, 2,4‐D and mesotrione‐based herbicides. These properties were achieved by introducing the dmo, pat, ft_t.1 and tdo expression cassettes. The molecular characterisation data and bioinformatics analyses do not identify issues requiring food/feed ...
EFSA Panel on Genetically Modified Organisms (GMO), Josep Casacuberta, Francisco Barro, Albert Braeuning, Ruud de Maagd, Michelle M. Epstein, Thomas Frenzel, Jean‐Luc Gallois, Frits Koning, Antoine Messéan, F. Javier Moreno, Fabien Nogué, Giovanni Savoini, Alan H. Schulman, Christoph Tebbe, Eve Veromann, Michele Ardizzone, Giacomo De Sanctis, Antonio Fernandez Dumont, Arianna Ferrari, Andrea Gennaro, Aina Belen Gil Gonzalez, José Ángel Gómez Ruiz, Tilemachos Goumperis, Dafni Maria Kagkli, Paolo Lenzi, Aleksandra Lewandowska, Ana M. Camargo, Franco Maria Neri, Pietro Piffanelli, Tommaso Raffaello, Elena Sánchez‐Brunete   +31 more
wiley   +1 more source

Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy. [PDF]

Nat Commun
Jadhav S, Maiorca M, Manigrasso J, Saha S, Rakitch A, Muscat S, Mulvaney T, De Vivo M, Topf M, Marcia M.   +9 more
europepmc   +1 more source

Controlled dynamic remodeling of the spliceosome active site enables the first step of splicing. [PDF]

Proc Natl Acad Sci U S A
Martino G, Manigrasso J, La Sala G, Marcia M, De Vivo M.   +4 more
europepmc   +1 more source

Pre-mRNA splicing and its regulation in microalgae and cyanobacteria. [PDF]

Adv Biotechnol (Singap)
Do S, Liu Y, Huynh H, Liu Y, Li W, Chen MX, Du ZY.   +6 more
europepmc   +1 more source

Cysteine Mutagenesis of a Group II Intron-Encoded Protein Supports Splicing, Mobility, and Site-Specific Labeling. [PDF]

Biochemistry
Harper JA, Starcovic SA, Billington N, Robart AR.   +3 more
europepmc   +1 more source