Results 121 to 130 of about 61,070 (218)

Patch‐Clamp‐ and 15N Isotope Tracer‐Based Techniques Reveal the Transport Characteristics of SlGAT1 and the Metabolic Flow of Exogenous GABA Under Salt Stress

Plant, Cell &Environment, EarlyView.
ABSTRACT γ‐Aminobutyric acid (GABA) plays an important role in plant growth, development, and stress resistance. Exogenous GABA works by increasing the content of endogenous GABA; therefore, GABA transport from the apoplast to the cytosol is critical. In this study, two GABA transporter genes, SlGAT1 and SlGAT2 were identified in tomato.
Ding Yuan, Xiao‐Lei Wu, Xiang‐Qun Jiang, Zu‐Wen Lan, Li‐Ran Zhao, Yun‐Duan Wang, Hong‐Bo Gao   +6 more
wiley   +1 more source

Factors determining chromosomal localization of transposable elements in plants

Plant Biology, EarlyView.
We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky, P. Jedlicka, M. Lexa, Z. Kubat   +3 more
wiley   +1 more source

Roots of Indian heliotrope (Heliotropium indicum) produce simple pyrrolizidine alkaloids using the same homospermidine oxidase involved in biosynthesis of complex pyrrolizidine alkaloids in aerial parts

Plant Biology, EarlyView.
Indian heliotrope uses the same oxidase to produce complex pyrrolizidine alkaloid esters in aerial parts and simple pyrrolizidine alkaloids in roots. Abstract Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites found in several plant lineages with independent evolutionary origins.
M. M. Zakaria, M.‐B. Salewski, D. Ober
wiley   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 282-307, July/August 2025.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]

, 2018
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan, Li, Lili, Tang, Lixu, Wang, Yan, Wang, Yibin, Wang, Zhihua, Xie, Yinping, Yu, Ling, Yu, Pengcheng, Zheng, Di   +9 more
core  

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 218-231, July 2025.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit M. Wollmann, Elisabet Størset, Jesse J. Swen, Henk‐Jan Guchelaar, Espen Molden, Marin M. Jukic, Magnus Ingelman‐Sundberg   +11 more
wiley   +1 more source

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
The interaction between m6A and APA is mediated by the m6A regulator IGF2BP2 and the APA factor CPSF6 The transcripts harbouring m6A modification tend to use the proximal polyadenylation signal (PAS) in ovarian cancer (OC) PUM2 promotes the malignant progression of OC through its m6A methylation and APA processing .
Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu   +14 more
wiley   +1 more source

FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
FTO regulates the translation of IGFBP3 by demethylating m6A sites in the 3′‐untranslated region of IGFBP3 mRNA. Binding of the m6A reader protein IMP3 to 3′UTR m6A sites in IGFBP3 mRNA promoted its localisation and sequestration in cellular organelles known as to P‐bodies, thereby suppressing IGFBP3 mRNA translation. IGFBP3 regulates activation of the
Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li   +7 more
wiley   +1 more source

Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Combination of Kras activation and Arid1a loss induces pancreatic cancer in mice. ARID1A deficiency enhances immune cell infiltration and lipid metabolism in pancreatic cancer. Fatty acid synthase (FASN) is a druggable target in ARID1A‐deficient pancreatic cancer.
Tzu‐Lei Kuo, Ya‐Chin Hou, Yan‐Shen Shan, Li‐Tzong Chen, Wen‐Chun Hung   +4 more
wiley   +1 more source

Genome‐Wide Identification and Expression Analysis of TaDES1 Gene Family Responded to Biotic and Abiotic Stress in Wheat (Triticum aestivum L.)

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
The TaDES1 gene family in wheat consists of 18 genes across 13 chromosomes, categorized into four subfamilies. Evolutionary analysis shows segmental duplication as a key driver of family expansion, with strong purifying selection. TaDES1 members play critical roles in stress response, phytohormone regulation, and plant growth and development, supported
Wenjie Kan, Yameng Gao, Ziqi Wang, Zhu Yang, Yuan Cheng, Dacheng Wang, Zhiwei Li, Caiguo Tang, Lifang Wu   +8 more
wiley   +1 more source