Results 121 to 130 of about 62,692 (225)

A Genetically Encoded Assay System to Quantify O‐GlcNAc Transferase (OGT) Activity in Live Cells

Angewandte Chemie, Volume 137, Issue 43, October 20, 2025.
A genetically encoded, imaging‐based reporter enables direct measurement of O‐GlcNAc transferase (OGT) activity in living cells. The system exploits OGT‐dependent proteolysis of HCF‐1 to drive nuclear and cytoplasmic redistribution of fluorescent signals, allowing cell‐by‐cell spatially resolved quantification of OGT activity.
Weifeng Benny Wu, Yanping Zhu, Jun Bian, Jil Busmann, David Vocadlo   +4 more
wiley   +2 more sources

Roots of Indian heliotrope (Heliotropium indicum) produce simple pyrrolizidine alkaloids using the same homospermidine oxidase involved in biosynthesis of complex pyrrolizidine alkaloids in aerial parts

Plant Biology, EarlyView.
Indian heliotrope uses the same oxidase to produce complex pyrrolizidine alkaloid esters in aerial parts and simple pyrrolizidine alkaloids in roots. Abstract Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites found in several plant lineages with independent evolutionary origins.
M. M. Zakaria, M.‐B. Salewski, D. Ober
wiley   +1 more source

The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B)

American Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.
ABSTRACT Glycogen storage disorders are a group of genetic disorders affecting glucose homeostasis in the body. Muscular glycogen stores are essential for liberating glucose for energy supply during bursts of activity and sustained muscle work. Muscle glycogen storage disease 0 (GSD0B) is associated with biallelic variants in GYS1 causing muscular ...
Sarah Donoghue, Smitha Kumble, Pontus Wasling, Lars Alberg, Pia Linton‐Dahlöf, Yilmaz Yildiz, İlker Ertuğrul, Terry Derks, Dwight Koeberl, Emmeline Lagrange, Sabrina Vergnaud, Lidia Pezzani, Maria Iascone, Zornitza Stark, Adam M. Bournazos, Sandra T. Cooper, Gittan Kollberg   +16 more
wiley   +1 more source

A Near Telomere‐To‐Telomere Genome Assembly of Coffea arabica (Mundo Novo) Provides Insights Into Its Secondary Metabolism

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Arabica coffee (Coffea arabica) dominates global coffee production, accounting for over 60% of the world's coffee trade. The Mundo Novo cultivar, predominantly grown in Yunnan, China, represents a significant germplasm resource. However, the absence of a high‐quality reference genome has hindered comprehensive genetic research and in‐depth ...
Yi Liu, Hang Zong, Yaowu Xing, Xi Jiao, Zhuoya Liu, Yusheng Niu, Zhiling Yang, Shimeng Liu, Yongqiang Wang, Haodong Zhao, Xianqing Chen, Zhenzhu Li, Xiao Wang, Jing Cai, Wen Wang, Zhongkai Wang   +15 more
wiley   +1 more source

A semi‐dominant NLR allele regulates growth and disease resistance in wheat

Plant Biotechnology Journal, Volume 23, Issue 11, Page 4694-4708, November 2025.
Summary Wheat powdery mildew is a significant threat to wheat production, necessitating the development of disease‐resistant varieties as an economically viable and environmentally sustainable strategy. In this study, we investigated a semi‐dominant mutant, necrosis leaf (necl), which exhibits spontaneous necrotic lesions and enhanced resistance to ...
Shuiquan Tian, Tingting Du, Jianqing Niu, Shusong Zheng, Zhimeng Zhang, Hongwei Li, Qian‐Hua Shen, Hong‐Qing Ling, Yaoqi Si   +8 more
wiley   +1 more source

pseudo‐GhFAD2‐1 Is a lncRNA Involved in Regulating Cottonseed Oleic and Linoleic Acid Ratios and Seed Size in Gossypium hirsutum

Plant Biotechnology Journal, Volume 23, Issue 11, Page 5229-5251, November 2025.
ABSTRACT Long non‐coding RNAs (lncRNAs), defined as transcripts > 200 nt without protein‐coding capacity, play crucial regulatory roles in plant growth and development. While numerous lncRNAs exist in plants including cotton (Gossypium spp.), few are functionally characterised. G. hirsutum serves as both a premier fibre crop and significant oil source,
Haihong Chen, Yanjun Li, XianPeng Xiong, Xuan Liu, Fei Xue, Jie Sun, Qian‐Hao Zhu, Feng Liu   +7 more
wiley   +1 more source

Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The figure illustrates in vitro (melatonin‐treated C2C12 myoblasts) and in vivo (mouse frostbite‐induced tibialis anterior muscle injury with melatonin administration) models. Melatonin activates AMPK, which phosphorylates PGC‐1α to enhance mitochondrial bioenergetics (decreased ROS and LDH, increased ATP, mtDNA, membrane potential, and oxygen ...
Wei Xie, Zhengchao Hong, Yuxin Xie, Kangyan Hou, Songhan Li, Mingxin Fang, Yupeng Guan, Zhixuan Zhang, Miao Zhang   +8 more
wiley   +1 more source

The influence of glutathione S-transferases M1 and M3 on the development of bladder cancer [PDF]

Problem: Cigarette smoking is the most important risk factor of transitional cell carcinoma of the urinary bladder. The effect of the glutathione S- transferases M1 (GSTM1) and M3 (GSTM3) on the influence of this risk factor was investigated.
Bolt, Hermann M., Golka, Klaus, Schmidt, Tobias, Selinski, Silvia   +3 more
core  

Presence of group II introns in phage genomes. [PDF]

Nucleic Acids Res
Merk LN, Jones TA, Eddy SR.
europepmc   +1 more source

Integrating experimental feedback improves generative models for biological sequences. [PDF]

Nucleic Acids Res
Calvanese F, Peinetti G, Pavlinova P, Nghe P, Weigt M.   +4 more
europepmc   +1 more source