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Two universally conserved adenosines of the group I intron that are important for self-splicing but not for core catalytic activity.

Journal of biochemistry, 1994
Two adenosine residues, universally conserved among group I introns, are located in the L4 region of the catalytic core. Base-substitution mutations in these adenosines resulted in diminished in vitro self-splicing activity of the Tetrahymena group I intron, more severely for double than for single mutations. The defect caused by the mutation of the L4
K P, Williams, D N, Fujimoto, T, Inoue
openaire   +1 more source

Antibiotic inhibition of RNA catalysis: neomycin B binds to the catalytic core of the td group I intron displacing essential metal ions.

Journal of molecular biology, 1998
The aminoglycoside antibiotic neomycin B induces misreading of the genetic code during translation and inhibits several ribozymes. The self-splicing group I intron derived from the T4 phage thymidylate synthase (td) gene is one of these. Here we report how neomycin B binds to the intron RNA inhibiting splicing in vitro.
I, Hoch   +3 more
openaire   +1 more source

Cancer statistics for African American/Black People 2022

Ca-A Cancer Journal for Clinicians, 2022
Angela Giaquinto   +2 more
exaly  

Cancer statistics for the US Hispanic/Latino population, 2021

Ca-A Cancer Journal for Clinicians, 2021
Kimberly D Miller   +2 more
exaly  

Cancer statistics for adolescents and young adults, 2020

Ca-A Cancer Journal for Clinicians, 2020
Kimberly D Miller   +2 more
exaly  

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