RNA folding and catalysis mediated by iron (II). [PDF]
PLoS ONE, 2012 Mg²⁺ shares a distinctive relationship with RNA, playing important and specific roles in the folding and function of essentially all large RNAs. Here we use theory and experiment to evaluate Fe²⁺ in the absence of free oxygen as a replacement for Mg²⁺ in
Shreyas S Athavale +13 more
doaj +1 more source
Template-jumping prime editing enables large insertion and exon rewriting in vivo
Nature Communications, 2023 Targeted insertion of large DNA fragments holds promise for genome engineering and gene therapy. Prime editing (PE) effectively inserts short (400 bp) remains low and in vivo application has not been demonstrated.
Chunwei Zheng +5 more
doaj +1 more source
Biology, 2017 A bimolecular ribozyme consisting of a core ribozyme (ΔP5 RNA) and an activator module (P5abc RNA) has been used as a platform to design assembled RNA nanostructures.
Md. Motiar Rahman +2 more
doaj +1 more source
DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]
, 2017 Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao +6 more
core +3 more sources
Homing endonuclease I-TevIII: dimerization as a means to a double-strand break [PDF]
, 2007 Homing endonucleases are unusual enzymes, capable of recognizing lengthy DNA sequences and cleaving site-specifically within genomes. Many homing endonucleases are encoded within group I introns, and such enzymes promote the mobility reactions of these ...
Athanasiadis +53 more
core +2 more sources
, 1998 Introns interrupt the continuity of many eukaryal genes, and therefore their removal by splicing is a crucial step in gene expression. Interestingly, even within Eukarya there are at least four splicing mechanisms.
Abelson, John +2 more
core +1 more source
Mechanism of DNA target site recognition by group II introns TeI3c and GsI-IIC and splicing activity of GsI-IIC reverse transcriptase [PDF]
, 2017 Mobile group II introns are self-catalytic ribozymes found in bacteria and eukaryotic organelles. They can mobilize within the genomes by retrohoming, which involves RNA-catalyzed splicing followed by the excised intron reverse splicing into a target ...
Kang, Sean Yoon-Seo
core +1 more source
Group I Intron Internal Guide Sequence Binding Strength as a Component of Ribozyme Network Formation
Molecules, 2016 Origins-of-life research requires searching for a plausible transition from simple chemicals to larger macromolecules that can both hold information and catalyze their own production.
Laura Elizabeth Satterwhite +2 more
doaj +1 more source
Molecular rules for selectivity in lipase-catalysed acylation of lysine [PDF]
Process Biochemistry, Elsevier, 2018, 74, pp.50-60, 2019 The selectivity of L-lysine acylation by lauric acid catalysed by Candida antarctica lipase B (CALB) was investigated combining experimental and theoretical methodologies. Experiments showed the near-exclusive acylation of lysine $\epsilon$-amino group; only traces of product resulting from the acylation of lysine $\alpha$-amino group were observed ...
arxiv +1 more source
Origin of the electrocatalytic activity in carbon nanotube fiber counter-electrodes for solar-energy conversion [PDF]
, 2021 However, their electrocatalytic activity is still poorly understood. This work deciphers the origin of the catalytic activity of counter-electrodes (CEs)/current collectors made of self-standing carbon nanotubes fibers (CNTfs) using Co$^(+2)$/Co$^(+3)$ redox couple electrolytes.
arxiv +1 more source