Results 191 to 200 of about 60,524 (204)

Antibiotic inhibition of RNA catalysis: neomycin B binds to the catalytic core of the td group I intron displacing essential metal ions 1 1Edited by M. Yaniv

Journal of Molecular Biology, 1998
The aminoglycoside antibiotic neomycin B induces misreading of the genetic code during translation and inhibits several ribozymes. The self-splicing group I intron derived from the T4 phage thymidylate synthase (td) gene is one of these. Here we report how neomycin B binds to the intron RNA inhibiting splicing in vitro.
I Hoch, Christian Berens, E. Westhof, Renée Schroeder   +3 more
semanticscholar   +5 more sources

RNA as a Drug Target: Recent Patents on the Catalytic Activity of Trans- Splicing Ribozymes Derived from Group I Intron RNA

Recent Patents on DNA & Gene Sequences, 2010
The importance of RNA in vital cellular events like gene expression, transport, self-splicing catalytic activity etc., renders them an alternative target for drugs and other specific RNA binding ligands. RNA targets gain significance for the fact that targeting DNA with therapeutics sooner leads to drug resistance and severe side effects by impairing ...
Irudayam Maria Johnson
semanticscholar   +5 more sources

Deletion of P9 and stem-loop structures downstream from the catalytic core affects both 5' and 3' splicing activities in a group-I intron

Gene, 1994
The P9 stem-loop is one of the conserved structural elements found in all group-I introns. Using two deletion mutants in this region of the Tetrahymena thermophilia large ribosomal subunit intron, we show that removal of the P9 element, either alone, or together with the non-conserved downstream P9.1 and P9.2 elements, results in an intron incapable of
Mark G. Caprara, Richard B. Waring
semanticscholar   +5 more sources

Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns

Nature, 1990
Understanding the mechanisms by which ribozymes catalyse chemical reactions requires a detailed knowledge of their structure. The secondary structure of the group I introns has been confirmed by comparison of over 70 published sequences, by chemical protection studies, and by genetic experiments involving compensatory mutations.
François Michel, Andrew D. Ellington, Sandra Couture, Jack W. Szostak   +3 more
openalex   +4 more sources

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

Journal of Molecular Biology, 1990
Alignment of the 87 available sequences of group I self-splicing introns reveals numerous instances of covariation between distant sites. Some of these covariations cannot be ascribed to historical coincidences or the known secondary structure of group I introns, and are, therefore, best explained as reflecting tertiary contacts.
François Michel, Éric Westhof
openalex   +4 more sources

The catalytic group-I introns of the psbA gene of Chlamydomonas reinhardtii : core structures, ORFs and evolutionary implications

Current Genetics, 1999
The sequences and predicted secondary structures of the four catalytic group-I introns in the psbA gene of Chlamydomonas reinhardtii, Cr.psbA-1-Cr.psbA-4, have been determined. Cr.psbA-1 and Cr.psbA-4 are subgroup-IA1 introns and have similar secondary structures, except at the 3' end where Cr.psbA-1 contains a large inverted-repeat domain.
S. Holloway, Nita N. Deshpande, David L. Herrin   +2 more
openalex   +4 more sources

Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns

Cell, 1992
We have used an in vitro reconstitution system to determine the effects of a large number of mutations in the highly conserved 5' terminal domain of the yeast U2 snRNA on pre-mRNA splicing. Whereas many mutations have little or no functional consequence, base substitutions in two regions were found to have drastic effects on pre-mRNA splicing.
David S. McPheeters, John Abelson
openalex   +4 more sources

Faculty Opinions recommendation of One RNA plays three roles to provide catalytic activity to a group I intron lacking an endogenous internal guide sequence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2009
Sabine Müller
openalex   +2 more sources

Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion ligands.

, 2005
Mary R. Stahley, Sabine Strobel
openalex   +2 more sources

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Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.

Chemical Reviews, 2018
Nuclear pre-mRNA splicing and group II intron self-splicing both proceed by two-step transesterification reactions via a lariat intron intermediate. Recently determined cryo-electron microscopy (cryo-EM) structures of catalytically active spliceosomes ...
W. P. Galej, N. Toor, A. Newman, K. Nagai   +3 more
semanticscholar   +1 more source