Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types [PDF]
, 2018 Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Alvaro, Domenico +12 more
core +1 more source
Rapid Targeted Gene Disruption in Bacillus Anthracis [PDF]
, 2013 Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen.
Ellington, Andrew +9 more
core +3 more sources
Measuring Belief Dynamics on Twitter [PDF]
arXiv, 2022 There is growing concern about misinformation and the role online media plays in social polarization. Analyzing belief dynamics is one way to enhance our understanding of these problems. Existing analytical tools, such as survey research or stance detection, lack the power to correlate contextual factors with population-level changes in belief dynamics.
arxiv
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum [PDF]
, 2010 Background: Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence.
Abbaszadeh, Fatemah +9 more
core +1 more source
Phylogeny of conserved adenines in linkers of Group-I introns [PDF]
, 2009 We have analyzed the linkers in group-I introns, a characteristic region that is crucial to the folding and splicing process of the folded RNA, in seventy sequences spreading across r-RNA, t-RNA and organelle genes from various organisms including algae,
Chandrasekhar Kesavan, Natarajan Ganesan
core +1 more source
GROUP I INTRON-DERIVED RIBOZYME REACTIONS [PDF]
, 2005 Group I introns are catalytic RNAs capable of self-splicing out of RNA transcripts. Ribozymes derived from these group I introns are used to explore the molecular recognition properties involved in intron catalysis.
Johnson, Ashley Kirtley
core +1 more source
Ubiquitin carboxyl-terminal hydrolases are required for period maintenance of the circadian clock at high temperature in Arabidopsis [PDF]
, 2019 Protein ubiquitylation participates in a number of essential cellular processes including signal transduction and transcription, often by initiating the degradation of specific substrates through the 26S proteasome. Within the ubiquitin-proteasome system,
Coupland, George +6 more
core +1 more source
Nearest neighbour spacing distribution of basis in some intron-less and intron-containing DNA sequences [PDF]
Physica A 372 (2006) 368-373, 2006 We show that the nearest neighbour distribution of distances between basis pairs of some intron-less and intron-containing coding regions are the same when a procedure, called {\em unfolding}, is applied. Such a procedure consists in separating the secular variations from the oscillatory terms.
arxiv +1 more source
The aspartic proteinase family of three Phytophthora species [PDF]
, 2011 Background - Phytophthora species are oomycete plant pathogens with such major social and economic impact that genome sequences have been determined for Phytophthora infestans, P. sojae and P. ramorum.
Have, A., ten +3 more
core +1 more source
Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration [PDF]
, 2017 Endoribonucleases participate in almost every step of eukaryotic RNA metabolism, acting either as degradative or biosynthetic enzymes. We previously identified the founding member of the Eukaryotic EndoU ribonuclease family, whose components display ...
BOZZONI, Irene +11 more
core +1 more source