Results 81 to 90 of about 61,070 (218)

Structure of a Group II Intron Complexed with its Reverse Transcriptase

Nature Structural & Molecular Biology, 2016
Bacterial group II introns are large catalytic RNAs related to nuclear spliceosomal introns and eukaryotic retrotransposons. They self-splice to yield mature RNA, and integrate into DNA as retroelements.
Guosheng Qu, P. S. Kaushal, Jia Wang, H. Shigematsu, C. Piazza, R. Agrawal, M. Belfort, Hongwei Wang   +7 more
semanticscholar   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Structural basis for the second step of group II intron splicing

Nature Communications, 2018
The group II intron and the spliceosome share a common active site architecture and are thought to be evolutionarily related. Here we report the 3.7 Å crystal structure of a eukaryotic group II intron in the lariat-3′ exon form, immediately preceding the
R. Chan, J. Peters, A. Robart, T. Wiryaman, K. Rajashankar, N. Toor   +5 more
semanticscholar   +1 more source

Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain [PDF]

, 2014
Introduction: Approximately 100 million confirmed infections and 20,000 deaths are caused by Dengue virus (DENV) outbreaks annually. Global warming and rapid dispersal have resulted in DENV epidemics in formally non-endemic regions.
Carter, James R., Dawson, James L., Fraser, Malcolm J., Jr., Fraser, Tresa S., Higgs, Stephen, Horne, Kate M., Keith, James H., Kucharski, Cheryl A.   +7 more
core   +1 more source

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers, EarlyView.
PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Group II Intron Self-Splicing.

Annual Review of Biophysics, 2016
Group II introns are large, autocatalytic ribozymes that catalyze RNA splicing and retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants, fungi, and yeast and contributes to genetic variation in many bacteria ...
A. Pyle
semanticscholar   +1 more source

Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes [PDF]

, 2010
The exoskeleton or cuticle performs many key roles in the development and survival of all nematodes. This structure is predominantly collagenous in nature and requires numerous enzymes to properly fold, modify, process and cross-link these essential ...
Albertson, Antony P. Page, Bastin, Bird, Blaxter, Blelloch, Davis, Gallego, Gamble, Gamble, Ge, Gillian McCormack, Gillian Stepek, Hartigan, Hawdon, Hill, Hishida, Jones, Keskiaho, Kessler, Mitreva, Moerman, Möhrlen, Nelson, Novelli, Novelli, Opperman, Page, Redmond, Shamansky, Stepek, Studier, Stöcker, Stöcker, Suzuki, Thein, Van der Keyl, Williamson   +37 more
core   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

The Azoarcus Group I Intron Ribozyme Misfolds and Is Accelerated for Refolding by ATP-dependent RNA Chaperone Proteins*

Journal of Biological Chemistry, 2011
Background: Group I introns are valuable for studying RNA folding and chaperone proteins. Results: A catalytic activity assay was developed and used to demonstrate two prominent phases for Azoarcus ribozyme folding. The slow phase displays hallmarks of a
S. Sinan, Xiaoyan Yuan, R. Russell
semanticscholar   +1 more source

Protein phosphatase beta, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparum. [PDF]

, 1997
Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction. A putative protein serine/threonine phosphatase gene has been isolated from the human malaria parasite Plasmodium falciparum.
Arndt K. T., Barton G. J., Bruce M. C., Chen J., Chen J., Day K. P., Favre B., Kamibayashi C., Kennelly P. I., Lee J., Li I. L., Lin F. C., Lorca T., Nussenzweig R. S., Pallas D. C., Posas F., Rangachari K., Read L. K., Ronne H., Ross-MacDonald P. B., Shima H., Snaith H. A., Sneddon A. A., Stone S. R., Sutton A., Wera S., Xie H., Zhang Z., Zhang Z., Zhao Y., Zhao Y., Zhuo S., Zolnierowicz S.   +32 more
core   +1 more source