Results 101 to 110 of about 838,914 (323)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Occurrence frequency, molecular evolution and phylogenetic utility of Ulva-specific chloroplast group II intron infA-62 family

Frontiers in Marine Science
Chloroplast intron infA-62 as a degenerated group II intron family was previously observed to exist specifically in infA genes of chloroplast/plastid genomes (plastomes) in the genus Ulva (Ulvophyceae, Chlorophyta).
Feng Liu, Feng Liu, Feng Liu, Feng Liu, Shuangle Jin, Shuangle Jin, Shuangle Jin, Shuangle Jin, Jang Kyun Kim, Xiaochan Wu, Jing Wang, Jing Wang, Jing Wang, Jing Wang   +13 more
doaj   +1 more source

The Agaricus bisporus cox1 gene: the longest mitochondrial gene and the largest reservoir of mitochondrial group i introns. [PDF]

PLoS ONE, 2010
In eukaryotes, introns are located in nuclear and organelle genes from several kingdoms. Large introns (up to 5 kbp) are frequent in mitochondrial genomes of plant and fungi but scarce in Metazoa, even if these organisms are grouped with fungi among the ...
Cyril Férandon, Serge Moukha, Philippe Callac, Jean-Pierre Benedetto, Michel Castroviejo, Gérard Barroso   +5 more
doaj   +1 more source

Group II Intron-Mediated Trans-Splicing in the Gene-Rich Mitochondrial Genome of an Enigmatic Eukaryote, Diphylleia rotans

Genome Biology and Evolution, 2016
Although mitochondria have evolved from a single endosymbiotic event, present day mitochondria of diverse eukaryotes display a great range of genome structures, content and features.
Ryoma Kamikawa, Takashi Shiratori, K. Ishida, H. Miyashita, A. Roger   +4 more
semanticscholar   +1 more source

Group II intron–ribosome association protects intron RNA from degradation [PDF]

RNA, 2013
The influence of the cellular environment on the structures and properties of catalytic RNAs is not well understood, despite great interest in ribozyme function. Here we report on ribosome association of group II introns, which are ribozymes that are important because of their putative ancestry to spliceosomal introns and retrotransposons, their ...
Tao Huang, Tao Huang, Carol Lyn Piazza, Carol Lyn Piazza, Marlene Belfort, Marlene Belfort, Guosheng Qu, Lydia M. Contreras, Grant Gelderman, Dorie Smith, Dorie Smith, Rick Russell, Jeffrey P. Potratz   +12 more
openaire   +2 more sources

DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]

, 2017
Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao, Han, Jin, Heng, Xiao, Lee, William R, Miller, Jeff F, Naorem, Santa S, Wang, Shufang   +6 more
core   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

The mitochondrial LSU rRNA group II intron of Ustilago maydis encodes an active homing endonuclease likely involved in intron mobility. [PDF]

PLoS ONE, 2012
BACKGROUND: The a2 mating type locus gene lga2 is critical for uniparental mitochondrial DNA inheritance during sexual development of Ustilago maydis. Specifically, the absence of lga2 results in biparental inheritance, along with efficient transfer of ...
Anja Pfeifer, Bettina Martin, Jörg Kämper, Christoph W Basse   +3 more
doaj   +1 more source

An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation [PDF]

, 2017
Global transcriptome reprogramming during sper-matogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Sper-matocytes and spermatids require particularly exten-sive reprogramming of gene expression to switch from
Alberdi, Antonio J., Bielli, Pamela, De la Grange, Pierre, DI PERSIO, Sara, Geremia, Raffaele, Jolly, Ariane, Naro, Chiara, Sette, Claudio, Setterblad, Niclas, Vicini, Elena   +9 more
core   +2 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source