Results 111 to 120 of about 838,914 (323)
Natural circularly permuted group II introns in bacteria produce RNA circles
iScience, 2021 Summary: Group II self-splicing introns are large structured RNAs that remove themselves from transcripts while simultaneously sealing the resulting gaps.
Adam Roth +4 more
doaj
Evidence for a group II intron-like catalytic triplex in the spliceosome
Nature Structural &Molecular Biology, 2014 To catalyze pre-mRNA splicing, U6 small nuclear RNA positions two metals that interact directly with the scissile phosphates. U6 metal ligands correspond stereospecifically to metal ligands within the catalytic domain V of a group II self-splicing intron.
S. Fica +3 more
semanticscholar +1 more source
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]
, 2017 RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M +6 more
core +1 more source
Liver‐specific lncRNAs associated with liver cancers
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina +3 more
wiley +1 more source
Structural basis for exon recognition by a group II intron [PDF]
Nature Structural & Molecular Biology, 2008 Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure.
Kevin S. Keating +4 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2020 We describe the plastome of Jenufa minuta, a unicellular green alga whose precise relationship with the Sphaeropleales (Chlorophyceae) remains uncertain.
Monique Turmel +3 more
doaj +1 more source
A novel multifunctional factor involved in trans-splicing of chloroplast introns in Chlamydomonas [PDF]
, 2017 In the chloroplast of Chlamydomonas reinhardtii, psaA mRNA is spliced in trans from three separate precursors which assemble to form two group II introns. A fourth transcript, tscA, completes the structure of the first intron.
Goldschmidt-Clermont, Michel +5 more
core
Influence of Dystrophin Isoform Deficiency on Motor Development in Duchenne Muscular Dystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In Duchenne muscular dystrophy (DMD), lack of the shorter dystrophin isoforms Dp140 and Dp71 is associated with increased central nervous system (CNS) involvement. We aimed to investigate how CNS involvement affects motor development in young DMD boys.
Mary Chesshyre +152 more
wiley +1 more source
Evolution of RNA-protein interactions: non-specific binding led to RNA splicing activity of fungal mitochondrial tyrosyl-tRNA synthetases. [PDF]
PLoS Biology, 2014 The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new function as a group I intron splicing factor by acquiring the ability to bind group I intron RNAs and stabilize their catalytically active RNA structure ...
Lilian T Lamech +2 more
doaj +1 more source