Results 161 to 170 of about 185,318 (333)

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase [PDF]

, 2010
Shan-Qing Gu, Xiaoxia Cui, Sijiong Mou, Sabine Mohr, Jun Yao, Alan M. Lambowitz   +5 more
openalex   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

SHAPE Profiling to Probe Group II Intron Conformational Dynamics During Splicing. [PDF]

Methods Mol Biol, 2021
Wiryaman T, Toor N.
europepmc   +1 more source

Isolation and Characterization of Group II Introns from Pseudomonas alcaligenes and Pseudomonas putida

, 2001
Chew Chieng Yeo, Sheree Yiin, Bee Huat Tan, Chit Laa Poh   +3 more
openalex   +2 more sources

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

Detection of a Group II Intron without an Open Reading Frame in the Alpha-Toxin Gene ofClostridium perfringensIsolated from a Broiler Chicken

, 2006
Menglin Ma, Kaori Ohtani, Tohru Shimizu, Naoaki Misawa   +3 more
openalex   +2 more sources

A member of a novel Arabidopsis thaliana gene family of candidate Mg²⁺ ion transporters complements a yeast mitochondrial group II intron‐splicing mutant [PDF]

, 2000
Irene Schock, Juraj Gregáň, S. Steinhäuser, Rudolf J. Schweyen, Axel Brennicke, Volker Knoop   +5 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Conjugation mediates transfer of the Ll.LtrB group II intron between different bacterial species [PDF]

, 2004
Kamila Belhocine, Isabelle Plante, Benoit Cousineau   +2 more
openalex   +1 more source