Results 181 to 190 of about 185,318 (333)
Genomic Heterogeneity in a Natural Archaeal Population Suggests a Model of tRNA Gene Disruption [PDF]
, 2012 FUJISHIMA, Kosuke +15 more
core +1 more source
Visualizing metal-ion-binding sites in group I introns by iron(II)-mediated Fenton reactions
, 1998 Christian Berens +3 more
openalex +1 more source
Annals of Neurology, EarlyView.Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji +10 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell +3 more
wiley +1 more source
Self-splicing RNA circularization facilitated by intact group I and II introns
Nature CommunicationsCircular RNA (circRNA) has gained significant attention in RNA therapeutics due to its enhanced stability and protein-coding potential. In this study, we present two in vitro RNA circularization techniques, namely Permuted Intron-Exon through Trans ...
Yong Shen +9 more
doaj +1 more source
The effect of metal ions on splice site formation of group II intron ribozymes
, 2008 Daniela Kruschel
openalex +1 more source
The group II intron ribonucleoprotein precursor is a large, loosely packed structure [PDF]
, 2010 Tao Huang +7 more
openalex +1 more source
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Angewandte Chemie International Edition, EarlyView.Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer +11 more
wiley +1 more source
Enzyme engineering through evolution: Thermostable recombinant group II intron reverse transcriptases provide new tools for RNA research and biotechnology [PDF]
, 2013 Kathleen Collins, Timothy W. Nilsen
openalex +1 more source
Animal Research and One Health, EarlyView.The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang +5 more
wiley +1 more source