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Group II Introns: Mobile Ribozymes that Invade DNA [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Group II introns are mobile ribozymes that self-splice from precursor RNAs to yield excised intron lariat RNAs, which then invade new genomic DNA sites by reverse splicing. The introns encode a reverse transcriptase that stabilizes the catalytically active RNA structure for forward and reverse splicing, and afterwards converts the integrated intron RNA
Alan M. Lambowitz, Steven Zimmerly
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Evolution of group II introns [PDF]
Mobile DNA, 2015 Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns. Despite long-standing speculation, there is limited understanding about the actual pathway by which group II introns evolved into eukaryotic introns.
Zimmerly, Steven, Semper, Cameron
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Structure determination of group II introns [PDF]
Methods, 2017 Group II introns are self-splicing catalytic RNAs that are able to excise themselves from pre-mRNAs using a mechanism identical to that utilized by the spliceosome. Both structural and phylogenetic data support the hypothesis that group II introns and the spliceosome share a common ancestor.
Timothy Wiryaman, Navtej Toor
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Database for bacterial group II introns [PDF]
Nucleic Acids Research, 2011 The Database for Bacterial Group II Introns (http://webapps2.ucalgary.ca/~groupii/index.html#) provides a catalogue of full-length, non-redundant group II introns present in bacterial DNA sequences in GenBank. The website is divided into three sections.
Candales, Manuel A. +9 more
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Database for mobile group II introns [PDF]
Nucleic Acids Research, 2003 Group II introns are self-splicing RNAs and retroelements found in bacteria and lower eukaryotic organelles. During the past several years, they have been uncovered in surprising numbers in bacteria due to the genome sequencing projects; however, most of the newly sequenced introns are not correctly identified.
Lixin, Dai +4 more
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Group II intron–ribosome association protects intron RNA from degradation [PDF]
RNA, 2013 The influence of the cellular environment on the structures and properties of catalytic RNAs is not well understood, despite great interest in ribozyme function. Here we report on ribosome association of group II introns, which are ribozymes that are important because of their putative ancestry to spliceosomal introns and retrotransposons, their ...
Contreras, Lydia M. +8 more
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Phylogenetic relationships among group II intron ORFs [PDF]
Nucleic Acids Research, 2001 Group II introns are widely believed to have been ancestors of spliceosomal introns, yet little is known about their own evolutionary history. In order to address the evolution of mobile group II introns, we have compiled 71 open reading frames (ORFs) related to group II intron reverse transcriptases and subjected their derived amino acid sequences to ...
S, Zimmerly, G, Hausner, , Wu Xc
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Group II Introns: Highly Structured yet Dynamic
CHIMIA, 2023 RNA splicing, the removal of introns and ligation of exons, is a crucial process during mRNA maturation. Group II introns are large ribozymes that self-catalyze their splicing, as well as their transposition. They are living fossils of spliceosomal introns and eukaryotic retroelements.
Ahunbay, Esra +2 more
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Bacterial group II introns: not just splicing [PDF]
FEMS Microbiology Reviews, 2007 Group II introns are both catalytic RNAs (ribozymes) and mobile retroelements that were discovered almost 14 years ago. It has been suggested that eukaryotic mRNA introns might have originated from the group II introns present in the alphaproteobacterial progenitor of the mitochondria.
Nicolás, Toro +2 more
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Global Regulators Orchestrate Group II Intron Retromobility [PDF]
Molecular Cell, 2009 Group II introns are hypothesized to share common ancestry with both nuclear spliceosomal introns and retrotransposons, which collectively occupy the majority of genome space in higher eukaryotes. These phylogenetically diverse introns are mobile retroelements that move through an RNA intermediate.
Coros, Colin J. +4 more
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