Characterization of a Group II Intron and its Intron-Encoded Protein
, 2016 Group II introns are a class of mobile genetic elements found in the genomes of bacteria, archaea and in the organellar genomes of some eukaryotes. They are comprised of a large structural RNA with ribozyme activity and a multi-functional intron-encoded protein. The IEP encodes four domains: reverse-transcriptase, maturase, DNA-binding and endonuclease
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Group II intron as cold sensor for self-preservation and bacterial conjugation. [PDF]
Nucleic Acids Res, 2020 Dong X, Qu G, Piazza CL, Belfort M.
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Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis
Arthritis &Rheumatology, EarlyView.Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar +2 more
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Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. [PDF]
Nucleic Acids Res, 2020 Liu N +7 more
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Dysregulation of U12‐Type Splicing in Lupus Neutrophils
Arthritis &Rheumatology, Accepted Article.Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco +11 more
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Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo
Chemistry – A European Journal, EarlyView.This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova +2 more
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Mapping divalent metal ion binding sites in a group II intron by Mn2+‐ and Zn2+‐induced site‐specific RNA cleavage [PDF]
, 2001 Maren Hertweck, Manfred W. Mueller
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Arabidopsis AUGMIN8 Contains Two Independent Microtubule Association Domains
Cytoskeleton, EarlyView.ABSTRACT Plant cells create a plasma membrane‐associated network of microtubules that are nucleated by γ‐tubulin ring complexes primarily through microtubule‐dependent microtubule nucleation (MDMN). This dynamic array organizes into specific patterns in response to developmental and environmental cues to influence primary cell wall construction.
Naveen K. Chana +2 more
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A functional twintron, 'zombie' twintrons and a hypermobile group II intron invading itself in plant mitochondria. [PDF]
Nucleic Acids Res, 2020 Zumkeller S, Gerke P, Knoop V.
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Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns [PDF]
John Mattick +2 more
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