Results 201 to 210 of about 757,384 (292)

Demonstration that the Group II Intron from the Clostridial Conjugative Transposon Tn 5397 Undergoes Splicing In Vivo

open access: green, 2001
Adam P. Roberts   +3 more
openalex   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

open access: yesEpilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola   +3 more
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

open access: yesExploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang   +6 more
wiley   +1 more source

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

open access: yesExploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen   +29 more
wiley   +1 more source

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

open access: yesAdvanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

New Strategies for Exploring RNA's 2′-OH Expose the Importance of Solvent during Group II Intron Catalysis [PDF]

open access: bronze, 2004
Peter M. Gordon   +6 more
openalex   +1 more source

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