Development of a gene knockout system for Ralstonia eutropha H16 based on the broad-host-range vector expressing a mobile group II intron [PDF]
, 2010 Jong Myoung Park +3 more
openalex +1 more source
International Journal of Cancer, EarlyView.What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago +3 more
wiley +1 more source
A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp. [PDF]
Nucleic Acids Res, 2019 García-Rodríguez FM +4 more
europepmc +1 more source
Differential chemical probing of a group II self-splicing intron identifies bases involved in tertiary interactions and supports an alternative secondary structure model of domain V [PDF]
, 1998 María Costa +2 more
openalex +1 more source
International Journal of Cancer, EarlyView.Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer +11 more
wiley +1 more source
Optimal molecular crowding accelerates group II intron folding and maximizes catalysis. [PDF]
Proc Natl Acad Sci U S A, 2018 Paudel BP +4 more
europepmc +1 more source
Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma
International Journal of Cancer, EarlyView.What's New? The progression of lung cancer from minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IA) is a complex process involving molecular and microenvironment changes. Key molecular events that drive the invasion process, however, remain poorly characterized. In this comparison of gene profiles and differentially mutated genes in
Biqin Mou +19 more
wiley +1 more source
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries [PDF]
, 2018 Borecki, Ingrid +13 more
core +1 more source
Crystal Structure of a Self-Spliced Group II Intron
, 2008 Navtej Toor +3 more
openalex +2 more sources
The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia
International Journal of Cancer, EarlyView.Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch +5 more
wiley +1 more source