Results 251 to 260 of about 775,451 (311)
Restriction for gene insertion within the Lactococcus lactis Ll.LtrB group II intron
, 2006 Isabelle Plante, Benoit Cousineau
openalex +1 more source
Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling
The Journal of Pathology, EarlyView.Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto +27 more
wiley +1 more source
Localization of a bacterial group II intron-encoded protein in human cells. [PDF]
Sci Rep, 2015 Reinoso-Colacio M +5 more
europepmc +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Hemophilia A (HA) is a rare bleeding disorder caused by coagulation factor VIII (FVIII) deficiency. Prophylactic FVIII replacement therapy is essential for preventing bleeds, but it carries a risk of inhibitor development, especially in previously untreated and minimally treated patients (PUPs and MTPs, respectively).
Sarina Levy‐Mendelovich +11 more
wiley +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Multiple physical forms of excised group II intron RNAs in wheat mitochondria
, 2006 Jennifer Li‐Pook‐Than, Linda Bonen
openalex +1 more source
Preliminary genetic barcodes for ash (Fraxinus) species and generation of new wide hybrids
PLANTS, PEOPLE, PLANET, EarlyView.Societal Impact Statement The world‐wide diversity of ash trees includes genetic information encoding resistance to the ash dieback fungus and the emerald ash borer beetle, which are currently devastating ash populations in Europe and North America. In order to mobilise this genetic diversity in conventional breeding programmes, we need to be able to ...
William J. Plumb +11 more
wiley +1 more source
Artificial Intelligence and the Evolving Landscape of Immunopeptidomics
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Background Immunopeptidomics is the large‐scale study of peptides presented by major histocompatibility complex (MHC) molecules and plays a central role in neoantigen discovery and cancer immunotherapy. However, the complexity of mass spectrometry data, the diversity of peptide sources, and variability in immune responses present major ...
Thanh Hoa Vo +4 more
wiley +1 more source
Confirmation of BIK and SAMHD1 as Prostate Cancer Susceptibility Genes
The Prostate, EarlyView.ABSTRACT Background To independently assess data for recently reported genes—BIK, SAMHD1, FAM111A, and AOX1—in which rare variants have been associated with prostate cancer (PCa) risk and aggressiveness. Methods The study included 4448 PCa cases from Johns Hopkins School of Medicine and 103,221 population‐based controls from the Genome Aggregation ...
Christian P. Pavlovich +11 more
wiley +1 more source