Results 261 to 270 of about 775,451 (311)

Pathology of a Canine Model of Localized Prostate Carcinoma

The Prostate, EarlyView.
ABSTRACT Background Dogs spontaneously develop prostate carcinoma (PC) and share prostate gland anatomy, physiology, and size to men. Over the last 15 years, we have developed and refined a canine model of focal PC to evaluate therapeutic‐diagnostic (theranostic) interventions.
Nathan K. Hoggard, Felipe M. Berg, Marlon R. Szczepaniak, Xinning Wang, Noriko Kantake, Gopalakrishnan Ramamurthy, Li Gong, Eric T. Hostnik, Krishan Kumar, Arijit Ghosh, Dong Luo, Michael V. Knopp, Jill M. Keller, Evan T. Keller, Agata A. Exner, James P. Basilion, Michael F. Tweedle, Thomas J. Rosol   +17 more
wiley   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

The RNA‐Puzzles Assessments of RNA‐Only Targets in CASP16

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT RNA‐Puzzles was launched in 2011 as a collaborative effort dedicated to advancing and improving RNA 3D structure prediction. The automatic evaluation protocols for comparisons between prediction and experiment developed within RNA‐Puzzles are applied to the 2024 CASP16 competition.
Eric Westhof, Hao Sun, Fan Bu, Zhichao Miao   +3 more
wiley   +1 more source

Control of two sucking insect pests, a whitefly (Bemisia tabaci) and a thrips (Frankliniella occidentalis), infesting hot peppers by spraying LDH‐formulated dsRNA

Pest Management Science, EarlyView.
A vacuolar type ATPase subunit B (vATPase‐B) gene is identified and expressed in the midgut of Bemisia tabaci and Frankliniella occidentalis. The double‐stranded RNA (dsRNA) specific to vATPase‐B was expressed in hot peppers by virus‐induced gene silencing (VIGS) and killed both whitefly and thrips.
Falguni Khan, Tae‐Geun Song, Yonggyun Kim   +2 more
wiley   +1 more source

Sensitivity of Irish Pyrenopeziza brassicae populations to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides

Pest Management Science, EarlyView.
For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur, Yong‐Ju Huang, Bruce DL Fitt, Steven Kildea   +3 more
wiley   +1 more source

Decreased DMI sensitivity of Plenodomus biglobosus (phoma of oilseed rape) associated with CYP51 substitution G476S

Pest Management Science, EarlyView.
Here, we report for the first time a target site mutation in the CYP51 gene of the oilseed rape phoma stem canker fungus Plenodomus biglobosus (Leptosphaeria biglobosa) that is associated with decreased sensitivity to sterol demethylation inhibitor fungicides.
Kevin M King, Liza M González‐Rodríguez, Joanna Kaczmarek, Małgorzata Jędryczka, Jonathan S West   +4 more
wiley   +1 more source

Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ‐ATF3‐Gpx4 Signaling Pathway in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Jujuboside B induces ferroptosis and overcomes radioresistance. ABSTRACT Jujuboside B (JJB) is a saponin extracted from the Ziziphus jujuba var. spinose and has been reported to have anticancer effects. However, the detailed mechanism of its anti‐cancer effect in non‐small cell lung cancer (NSCLC) remains unclear.
Tae Woo Kim, Seong‐Gyu Ko
wiley   +1 more source

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source

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Transposition of a group II intron

Nature, 1993
Among mobile genetic elements, self-splicing introns are of particular interest. They belong to either group I or group II depending on their three-dimensional structure. Homing, the systematic intron invasion of an intronless gene when it encounters its homologous intron-bearing allele, is the only means for intron mobility so far demonstrated.
Léon Belcour, Sellem Ch, Gaël Lecellier   +2 more
openaire   +3 more sources

Mobile Group II Introns

Annual Review of Genetics, 2004
▪ Abstract  Mobile group II introns, found in bacterial and organellar genomes, are both catalytic RNAs and retrotransposable elements. They use an extraordinary mobility mechanism in which the excised intron RNA reverse splices directly into a DNA target site and is then reverse transcribed by the intron-encoded protein.
Steven Zimmerly, Alan M. Lambowitz
openaire   +3 more sources