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The FASEB Journal, 1993
Group I and group II introns are two types of RNA enzymes, ribozymes, that catalyze their own splicing by different mechanisms. In this review, we summarize current information about the structures of group I and group II introns, their RNA-catalyzed reactions, the facilitation of RNA-catalyzed splicing by protein factors, and the ability of the ...
Alan M. Lambowitz +3 more
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Group I and group II introns are two types of RNA enzymes, ribozymes, that catalyze their own splicing by different mechanisms. In this review, we summarize current information about the structures of group I and group II introns, their RNA-catalyzed reactions, the facilitation of RNA-catalyzed splicing by protein factors, and the ability of the ...
Alan M. Lambowitz +3 more
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Retrotransposition of a bacterial group II intron
Nature, 2000Self-splicing group II introns may be the evolutionary progenitors of eukaryotic spliceosomal introns, but the route by which they invade new chromosomal sites is unknown. To address the mechanism by which group II introns are disseminated, we have studied the bacterial L1.LtrB intron from Lactococcus lactis.
Marlene Belfort +3 more
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STRUCTURE AND ACTIVITIES OF GROUP II INTRONS
Annual Review of Biochemistry, 1995Group II introns are found in eubacteria and eubacterial-derived, organellar genomes. They have ribozymic activities, by which they direct and catalyze the splicing of the exons flanking them. This chapter reviews the secondary structure and known tertiary interactions of the ribozymic component of group II introns in relation to the problems of ...
Jean-Luc Ferat, François Michel
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The ins and outs of group II introns
Trends in Genetics, 2001Group II introns have attracted considerable attention as ribozymes, mobile genetic elements and possible progenitors of nuclear spliceosomal introns. Major advances in understanding their catalytic structure and dispersal strategies have recently come from several model mitochondrial and bacterial self-splicing introns.
Linda Bonen, Jörg Vogel
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Self-Splicing Group II Introns
2021Group II introns are ubiquitous self-splicing ribozymes and retrotransposable elements evolutionarily and chemically related to the eukaryotic spliceosome, with potential applications as gene-editing tools. Recent biochemical, cellular, evolutionary, and structural data have captured the intron in multiple conformations at different stages of catalysis
Chillón, Isabel, Marcia, Marco
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Group II intron retroelements: function and diversity
Cytogenetic and Genome Research, 2005Group II introns are a class of retroelements capable of carrying out both self-splicing and retromobility reactions. In recent years, the number of known group II introns has increased dramatically, particularly in bacteria, and the new information is altering our understanding of these intriguing elements. Here we review the basic properties of group
Steven Zimmerly, Aaron R. Robart
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Group II self-splicing introns in bacteria
Nature, 1993Like nuclear premessenger introns, group II self-splicing introns are excised from primary transcripts as branched molecules, containing a 2'-5' phosphodiester bond. For this reason, it is widely believed that the ribozyme (catalytic RNA) core of group II introns, or some evolutionarily related molecule, gave rise to the RNA components of the ...
François Michel, Jean-Luc Ferat
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Group II introns: Elaborate ribozymes
Biochimie, 1996Group II introns are found in organelle genomes of plants, fungi and algae as well as in some bacteria. Some group II introns have been shown to self-splice in vitro and thus constitute examples of ribozymes. Their splicing pathway is analogous to the splicing pathway of nuclear pre-mRNA introns.
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Specialized lineages of bacterial group II introns
Biochimie, 2007The Avi.groEL intron of Azotobacter vinelandii, which interrupts the termination codon of the groEL gene, is shown to belong to a monophyletic subset of bacterial group II introns that share a large insertion at their 5' extremity and a peculiar genetic localization.
François Michel +3 more
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Intron Biology, Focusing on Group II Introns, the Ancestors of Spliceosomal Introns
2015Self-splicing group II introns are large ribozymes and mobile retroelements initially identified in the mitochondrial and chloroplast genomes of lower eukaryotes and plants and subsequently found in bacteria and archaea. Group II introns display structural, functional and mechanistic similarities to eukaryotic pre-mRNA nuclear introns, which may have ...
Francisco Martínez-Abarca +4 more
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