An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron. [PDF]
RNA, 2018 Group II introns and non-LTR retrotransposons encode a phylogenetically related family of highly processive reverse transcriptases (RTs) that are essential for mobility and persistence of these retroelements. Recent crystallographic studies on members of
Zhao C, Liu F, Pyle AM.
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Structure of a group II intron in complex with its reverse transcriptase. [PDF]
Nat Struct Mol Biol, 2016 Bacterial group II introns are large catalytic RNAs related to nuclear spliceosomal introns and eukaryotic retrotransposons. They self-splice to yield mature RNA, and integrate into DNA as retroelements.
Qu G +7 more
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Group II introns in the bacterial world [PDF]
Molecular Microbiology, 2000 Group II introns are large catalytic RNA molecules that act as mobile genetic elements. They were initially identified in the organelle genomes of lower eukaryotes and plants, and it has been suggested that they are the progenitors of nuclear spliceosomal introns.
Francisco Martínez‐Abarca +1 more
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Group II intron-anchored gene deletion in Clostridium. [PDF]
PLoS ONE, 2011 Clostridium plays an important role in commercial and medical use, for which targeted gene deletion is difficult. We proposed an intron-anchored gene deletion approach for Clostridium, which combines the advantage of the group II intron "ClosTron" system
Kaizhi Jia +3 more
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Optimal molecular crowding accelerates group II intron folding and maximizes catalysis. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Biological processes take place in living cells and have adapted to environmental conditions such as temperature, salt concentration, and high-density cellular contents.
Paudel BP +4 more
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Methylation of rRNA as a host defense against rampant group II intron retrotransposition [PDF]
Mobile DNA, 2021 Background Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing.
Justin M. Waldern +8 more
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Template-switching mechanism of a group II intron-encoded reverse transcriptase and its implications for biological function and RNA-Seq. [PDF]
J Biol Chem, 2019 The reverse transcriptases (RTs) encoded by mobile group II introns and other non-LTR retroelements differ from retroviral RTs in being able to template-switch efficiently from the 5′ end of one template to the 3′ end of another with little or no ...
Lentzsch AM +3 more
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Database for mobile group II introns [PDF]
Nucleic Acids Research, 2003 Group II introns are self-splicing RNAs and retroelements found in bacteria and lower eukaryotic organelles. During the past several years, they have been uncovered in surprising numbers in bacteria due to the genome sequencing projects; however, most of the newly sequenced introns are not correctly identified.
Lixin Dai
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A Glimpse of the Catalytic Core of a Group II Intron [PDF]
Structure, 2002 A paper in a recent issue of Science describes the first high-resolution structure of part of the catalytic core of a group II intron that will allow more detailed comparisons between the excision of introns by self-splicing group II introns and by nuclear pre-mRNA introns.
Charles C. Query
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A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp. [PDF]
Nucleic Acids Res, 2019 Group II introns are self-splicing mobile genetic retroelements. The spliced intron RNA and the intron-encoded protein (IEP) form ribonucleoprotein particles (RNPs) that recognize and invade specific DNA target sites.
García-Rodríguez FM +4 more
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