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Group II Introns: Flexibility and Repurposing
Frontiers in Molecular Biosciences, 2022 Maria Costa
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Group II Introns: Mobile Ribozymes that Invade DNA [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Group II introns are mobile ribozymes that self-splice from precursor RNAs to yield excised intron lariat RNAs, which then invade new genomic DNA sites by reverse splicing. The introns encode a reverse transcriptase that stabilizes the catalytically active RNA structure for forward and reverse splicing, and afterwards converts the integrated intron RNA
Alan M. Lambowitz, Steven Zimmerly
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Database for mobile group II introns [PDF]
Nucleic Acids Research, 2003 Group II introns are self-splicing RNAs and retroelements found in bacteria and lower eukaryotic organelles. During the past several years, they have been uncovered in surprising numbers in bacteria due to the genome sequencing projects; however, most of the newly sequenced introns are not correctly identified.
Lixin Dai
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Organellar Introns in Fungi, Algae, and Plants
Cells, 2021 Introns are ubiquitous in eukaryotic genomes and have long been considered as ‘junk RNA’ but the huge energy expenditure in their transcription, removal, and degradation indicate that they may have functional significance and can offer evolutionary ...
Jigeesha Mukhopadhyay, Georg Hausner
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Excision of Group II Introns as Circles [PDF]
Molecular Cell, 2001 Group II introns are usually removed from precursor RNAs as lariats comprised of a circular component and a short 3' tail. We find that group II introns can also be excised as complete circles. Circle formation requires release of the 3' exon of a splicing substrate, apparently by a trans splicing mechanism.
Heather L. Murray +6 more
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Evolution of group II introns [PDF]
Mobile DNA, 2015 Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns. Despite long-standing speculation, there is limited understanding about the actual pathway by which group II introns evolved into eukaryotic introns.
Zimmerly, Steven, Semper, Cameron
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Group II intron-based gene targeting reactions in eukaryotes. [PDF]
PLoS ONE, 2008 Mobile group II introns insert site-specifically into DNA target sites by a mechanism termed retrohoming in which the excised intron RNA reverse splices into a DNA strand and is reverse transcribed by the intron-encoded protein.
Marta Mastroianni +7 more
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Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]
, 2013 Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Best, AA +17 more
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The brown algae Pl.LSU/2 group II intron-encoded protein has functional reverse transcriptase and maturase activities. [PDF]
PLoS ONE, 2013 Group II introns are self-splicing mobile elements found in prokaryotes and eukaryotic organelles. These introns propagate by homing into precise genomic locations, following assembly of a ribonucleoprotein complex containing the intron-encoded protein ...
Madeleine Zerbato +5 more
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Frontiers in Microbiology, 2022 Group II introns (G2Is) are ribozymes that have retroelement characteristics in prokaryotes. Although G2Is are suggested to have been an important evolutionary factor in the prokaryote-to-eukaryote transition, comprehensive analyses of these introns ...
Masahiro C. Miura +9 more
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