Methylation of rRNA as a host defense against rampant group II intron retrotransposition [PDF]
Mobile DNA, 2021 Background Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing.
Justin M. Waldern +8 more
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Database for mobile group II introns [PDF]
Nucleic Acids Research, 2003 Group II introns are self-splicing RNAs and retroelements found in bacteria and lower eukaryotic organelles. During the past several years, they have been uncovered in surprising numbers in bacteria due to the genome sequencing projects; however, most of the newly sequenced introns are not correctly identified.
Lixin Dai
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A Glimpse of the Catalytic Core of a Group II Intron [PDF]
Structure, 2002 A paper in a recent issue of Science describes the first high-resolution structure of part of the catalytic core of a group II intron that will allow more detailed comparisons between the excision of introns by self-splicing group II introns and by nuclear pre-mRNA introns.
Charles C. Query
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Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing. [PDF]
Nucleic Acids Res, 2019 Although group II intron ribozymes are intensively studied the question how structural dynamics affects splicing catalysis has remained elusive. We report for the first time that the group II intron domain 6 exists in a secondary structure equilibrium ...
Plangger R +10 more
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Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. [PDF]
Nat Struct Mol Biol, 2016 Group II introns are self-splicing ribozymes that are essential in many organisms, and they have been hypothesized to share a common evolutionary ancestor with the spliceosome. Although structural similarity of RNA components supports this connection, it
Zhao C, Pyle AM.
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Group II Intron Self-Splicing.
Annual Review of Biophysics, 2016 Group II introns are large, autocatalytic ribozymes that catalyze RNA splicing and retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants, fungi, and yeast and contributes to genetic variation in many bacteria ...
A. Pyle
semanticscholar +4 more sources
A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp. [PDF]
Nucleic Acids Res, 2019 Group II introns are self-splicing mobile genetic retroelements. The spliced intron RNA and the intron-encoded protein (IEP) form ribonucleoprotein particles (RNPs) that recognize and invade specific DNA target sites.
García-Rodríguez FM +4 more
europepmc +2 more sources
Structural accommodations accompanying splicing of a group II intron RNP. [PDF]
Nucleic Acids Res, 2018 Group II introns, the putative progenitors of spliceosomal introns and retrotransposons, are ribozymes that are capable of self-splicing and DNA invasion. In the cell, group II introns form ribonucleoprotein (RNP) complexes with an intron-encoded protein,
Dong X +4 more
europepmc +2 more sources
Coevolution of group II intron RNA structures with their intron-encoded reverse transcriptases [PDF]
RNA: A publication of the RNA Society, 2001 Catalytic RNAs are often regarded as molecular fossils from the RNA World, yet it is usually difficult to get more specific information about their evolution.
Navtej Toor +2 more
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Development of a group II intron‐based genetic manipulation tool for Streptomyces [PDF]
Microbial BiotechnologyThe availability of an alternative and efficient genetic editing technology is critical for fundamental research and strain improvement engineering of Streptomyces species, which are prolific producers of complex secondary metabolites with significant ...
Ziwei Sang +4 more
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