Results 31 to 40 of about 775,451 (311)
Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. [PDF]
Nat Struct Mol Biol, 2016 Group II introns are self-splicing ribozymes that are essential in many organisms, and they have been hypothesized to share a common evolutionary ancestor with the spliceosome. Although structural similarity of RNA components supports this connection, it
Zhao C, Pyle AM.
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Annual Review of Biophysics, 2016 Group II introns are large, autocatalytic ribozymes that catalyze RNA splicing and retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants, fungi, and yeast and contributes to genetic variation in many bacteria.
A. Pyle
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Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing. [PDF]
Nucleic Acids Res, 2019 Although group II intron ribozymes are intensively studied the question how structural dynamics affects splicing catalysis has remained elusive. We report for the first time that the group II intron domain 6 exists in a secondary structure equilibrium ...
Plangger R +10 more
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Structural accommodations accompanying splicing of a group II intron RNP. [PDF]
Nucleic Acids Res, 2018 Group II introns, the putative progenitors of spliceosomal introns and retrotransposons, are ribozymes that are capable of self-splicing and DNA invasion. In the cell, group II introns form ribonucleoprotein (RNP) complexes with an intron-encoded protein,
Dong X +4 more
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Development of a group II intron‐based genetic manipulation tool for Streptomyces [PDF]
Microbial BiotechnologyThe availability of an alternative and efficient genetic editing technology is critical for fundamental research and strain improvement engineering of Streptomyces species, which are prolific producers of complex secondary metabolites with significant ...
Ziwei Sang +4 more
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Functionality of in vitro reconstituted group II intron RmInt1-derived ribonucleoprotein particles [PDF]
Frontiers in Molecular Biosciences, 2016 The functional unit of mobile group II introns is a ribonucleoprotein particle (RNP) consisting of the intron-encoded protein (IEP) and the excised intron RNA. The IEP has reverse transcriptase activity but also promotes RNA splicing, and the RNA-protein
María Dolores Molina-Sánchez +2 more
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Circularization pathway of a bacterial group II intron. [PDF]
Nucleic Acids Res, 2016 Group II introns are large RNA enzymes that can excise as lariats, circles or in a linear form through branching, circularization or hydrolysis, respectively. Branching is by far the main and most studied splicing pathway while circularization was mostly overlooked. We previously showed that removal of the branch point A residue from Ll.LtrB, the group
Monat C, Cousineau B.
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Did group II intron proliferation in an endosymbiont-bearing archaeon create eukaryotes? [PDF]
Biology Direct, 2006 Martin & Koonin recently proposed that the eukaryote nucleus evolved as a quality control mechanism to prevent ribosome readthrough into introns. In their scenario, the bacterial ancestor of mitochondria was resident in an archaeal cell, and group II ...
Poole Anthony M
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Group II Introns: Highly Structured yet Dynamic
CHIMIA, 2023 RNA splicing, the removal of introns and ligation of exons, is a crucial process during mRNA maturation. Group II introns are large ribozymes that self-catalyze their splicing, as well as their transposition.
Esra Ahunbay +2 more
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Identification of a family of group II introns encoding LAGLIDADG ORFs typical of group I introns [PDF]
RNA, 2002 Group I and group II introns are unrelated classes of introns that each encode proteins that facilitate intron splicing and intron mobility. Here we describe a new subfamily of nine introns in fungi that are group II introns but encode LAGLIDADG ORFs typical of group I introns. The introns have fairly standard group IIB1 RNA structures and are inserted
Navtej Toor, Steven Zimmerly
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