Results 71 to 80 of about 757,235 (157)

Evidence for a group II intron-like catalytic triplex in the spliceosome

Nature Structural &Molecular Biology, 2014
To catalyze pre-mRNA splicing, U6 small nuclear RNA positions two metals that interact directly with the scissile phosphates. U6 metal ligands correspond stereospecifically to metal ligands within the catalytic domain V of a group II self-splicing intron.
S. Fica, Melissa A. Mefford, J. Piccirilli, Jonathan P Staley   +3 more
semanticscholar   +1 more source

Evolution of RNA-protein interactions: non-specific binding led to RNA splicing activity of fungal mitochondrial tyrosyl-tRNA synthetases. [PDF]

PLoS Biology, 2014
The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new function as a group I intron splicing factor by acquiring the ability to bind group I intron RNAs and stabilize their catalytically active RNA structure ...
Lilian T Lamech, Anna L Mallam, Alan M Lambowitz   +2 more
doaj   +1 more source

The complete plastome of the coccoid green alga Jenufa minuta (Chlorophyceae, incertae sedis) unveils a noncanonical genetic code and a previously unrecognized trans-spliced group II intron in the rpl32 gene

Mitochondrial DNA. Part B. Resources, 2020
We describe the plastome of Jenufa minuta, a unicellular green alga whose precise relationship with the Sphaeropleales (Chlorophyceae) remains uncertain.
Monique Turmel, Antony T. Vincent, Christian Otis, Claude Lemieux   +3 more
doaj   +1 more source

A targetron system for gene targeting in thermophiles and its application in Clostridium thermocellum. [PDF]

PLoS ONE, 2013
Targetrons are gene targeting vectors derived from mobile group II introns. They consist of an autocatalytic intron RNA (a "ribozyme") and an intron-encoded reverse transcriptase, which use their combined activities to achieve highly efficient site ...
Georg Mohr, Wei Hong, Jie Zhang, Gu-zhen Cui, Yunfeng Yang, Qiu Cui, Ya-jun Liu, Alan M Lambowitz   +7 more
doaj   +1 more source

A loopy view of telomere evolution

Frontiers in Genetics, 2015
About a decade ago, I proposed that t-loops, the lariat structures adopted by many eukaryotic telomeres, could explain how the transition from circular to linear chromosomes was successfully negotiated by early eukaryotes.
Titia eDe Lange
doaj   +1 more source

Convergent Evolution of Fern-Specific Mitochondrial Group II Intron atp1i361g2 and Its Ancient Source Paralogue rps3i249g2 and Independent Losses of Intron and RNA Editing among Pteridaceae

Genome Biology and Evolution, 2016
Mitochondrial intron patterns are highly divergent between the major land plant clades. An intron in the atp1 gene, atp1i361g2, is an example for a group II intron specific to monilophytes (ferns). Here, we report that atp1i361g2 is lost independently at
Simon Zumkeller, V. Knoop, Nils Knie
semanticscholar   +1 more source

Crystal structure of group II intron domain 1 reveals a template for RNA assembly

Nature Chemical Biology, 2015
Although the importance of large noncoding RNAs is increasingly appreciated, our understanding of their structures and architectural dynamics remains limited.
Chen Zhao, K. Rajashankar, M. Marcia, A. Pyle   +3 more
semanticscholar   +1 more source

The chloroplastic DEVH-box RNA helicase INCREASED SIZE EXCLUSION LIMIT 2 involved in plasmodesmata regulation is required for group II intron splicing.

Plant, Cell and Environment, 2015
INCREASED SIZE EXCLUSION LIMIT 2 (ISE2) encodes a putative DEVH-box RNA helicase originally identified through a genetic screening for Arabidopsis mutants altered in plasmodesmata (PD) aperture.
Nicolas Carlotto, S. Wirth, N. Furman, Nazarena E. Ferreyra Solari, F. Ariel, M. Crespi, Ken-ichiro Kobayashi   +6 more
semanticscholar   +1 more source

A Novel Thermostable and Processive Reverse Transcriptase from a Group II Intron of Anoxybacillus flavithermus. [PDF]

Biomolecules, 2023
Oscorbin IP, Filipenko ML.
europepmc   +1 more source

A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron.

Genes & Development, 1997
The Lactococcus lactis group II intron Ll.ltrB is similar to mobile yeast mtDNA group II introns, which encode reverse transcriptase, RNA maturase, and DNA endonuclease activities for site-specific DNA insertion. Here, we show that the Lactococcal intron
M. Matsuura, R. Saldanha, R. Saldanha, Hongwen Ma, Hongwen Ma, H. Wank, H. Wank, Jian Yang, Georg Mohr, Georg Mohr, Stacey Cavanagh, G. Dunny, M. Belfort, A. Lambowitz, A. Lambowitz   +14 more
semanticscholar   +1 more source