Results 81 to 90 of about 185,318 (333)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun +95 more
wiley +1 more source
Comprehensive phylogenetic analysis of bacterial group II intron-encoded ORFs lacking the DNA endonuclease domain reveals new varieties. [PDF]
PLoS ONE, 2013 Group II introns are self-splicing RNAs that act as mobile retroelements in the organelles of plants, fungi and protists. They are also widely distributed in bacteria, and are generally assumed to be the ancestors of nuclear spliceosomal introns.
Nicolás Toro +1 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley +12 more
wiley +1 more source
Dwarfism with joint laxity in Friesian horses is associated with a splice site mutation in B4GALT7 [PDF]
, 2016 Background: Inbreeding and population bottlenecks in the ancestry of Friesian horses has led to health issues such as dwarfism. The limbs of dwarfs are short and the ribs are protruding inwards at the costochondral junction, while the head and back ...
Back, Willem +12 more
core +4 more sources
Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin +18 more
wiley +1 more source
Site-specific, insertional inactivation of incA in Chlamydia trachomatis using a group II intron. [PDF]
PLoS ONE, 2013 Chlamydia trachomatis is an obligate, intracellular bacterial pathogen that has until more recently remained recalcitrant to genetic manipulation.
Cayla M Johnson, Derek J Fisher
doaj +1 more source
A novel multifunctional factor involved in trans-splicing of chloroplast introns in Chlamydomonas [PDF]
, 2017 In the chloroplast of Chlamydomonas reinhardtii, psaA mRNA is spliced in trans from three separate precursors which assemble to form two group II introns. A fourth transcript, tscA, completes the structure of the first intron.
Goldschmidt-Clermont, Michel +5 more
core
Advanced Healthcare Materials, EarlyView.Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae +9 more
wiley +1 more source
A group III intron is formed from domains of two individual group II introns. [PDF]
Genes & Development, 1994 A 1352-nucleotide intron within the Euglena gracilis chloroplast ycf8 gene has been characterized as a complex twintron with overlapping internal introns and alternative splicing pathways. Partially spliced pre-mRNAs were characterized by a combination of cDNA cloning and sequencing, Northern hybridization, and S1 nuclease protection analyses.
L, Hong, R B, Hallick
openaire +2 more sources
Frontiers in Marine ScienceChloroplast intron infA-62 as a degenerated group II intron family was previously observed to exist specifically in infA genes of chloroplast/plastid genomes (plastomes) in the genus Ulva (Ulvophyceae, Chlorophyta).
Feng Liu +13 more
doaj +1 more source