Results 71 to 80 of about 15,121,811 (367)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Median inverse problem and approximating the number of $k$-median inverses of a permutation

, 2011
We introduce the "Median Inverse Problem" for metric spaces. In particular, having a permutation $\pi$ in the symmetric group $S_n$ (endowed with the breakpoint distance), we study the set of all $k$-subsets $\{x_1,...,x_k\}\subset S_n$ for which $\pi ...
da Silva, Poly H., Jamshidpey, Arash, Sankoff, David   +2 more
core   +10 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The $M$-matrix group inverse problem for distance-biregular graphs [PDF]

, 2022
Aida Abiad, Ángeles Carmona Mejías, A.M. Encinas, María José Jiménez   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Additive Results of Group Inverses in Banach Algebras

Mathematics
In this paper, we present new presentations of group inverses for the sum of two group invertible elements in a Banach algebra. We then apply these results to block complex matrices.
Dayong Liu, Huanyin Chen
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

m-Weak group MP inverse

Journal of Algebra and Its Applications
In this paper, we introduce a new matrix decomposition called the [Formula: see text]-core-nilpotent decomposition which is an extension of the core-nilpotent decomposition. By this new decomposition, we propose a new generalized inverse named the [Formula: see text]-weak group MP inverse which unifies the DMP-inverse and weak core inverse.
Wanlin Jiang, Jiale Gao, Xiangyu Zhang, Shengxi Zuo   +3 more
openaire   +2 more sources

Group velocity inversion in AlGaAs nanowires

Optics Express, 2007
We investigated the dispersion characteristics of submicron sized AlGaAs waveguides. Numerical simulations shows that the tight confinement of the optical waves in such nanowires leads to strong variations of the dispersion characteristics compared to classic, weakly guided waveguides of the same material system.
J, Meier, W S, Mohammed, A, Jugessur, L, Qian, M, Mojahedi, J S, Aitchison   +5 more
openaire   +2 more sources