Results 51 to 60 of about 1,732,355 (284)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Hua type integrals over unitary groups and over projective limits of unitary groups
, 2001 We discuss some natural maps from a unitary group U(n) to a smaller group U(n-m) (these maps are versions of the Livshic characteristic function). We calculate explicitly the direct images of the Haar measure under some maps.
Neretin, Yurii A.
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Combinatorial Gelfand models for some semigroups and q-rook monoid algebras [PDF]
, 2007 Inspired by the results of [R. Adin, A. Postnikov, Y. Roichman, Combinatorial Gelfand model, preprint math.RT arXiv:0709.3962], we propose combinatorial Gelfand models for semigroup algebras of some finite semigroups, which include the symmetric inverse ...
Kudryavtseva, Ganna +1 more
core +1 more source
The topological Hawaiian earring group does not embed in the inverse limit of free groups
, 2005 Endowed with natural topologies, the fundamental group of the Hawaiian earring continuously injects into the inverse limit of free groups. This note shows the injection fails to have a continuous inverse.
Fabel, Paul Fabel
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
On Radon transforms on finite groups [PDF]
, 2015 If $G$ is a finite group, is a function $f:G\to\mathbb C$ determined by its sums over all cosets of cyclic subgroups of $G$? In other words, is the Radon transform on $G$ injective? This inverse problem is a discrete analogue of asking whether a function
Ilmavirta, Joonas
core
Inverse renormalization group based on image super-resolution using deep convolutional networks
Scientific Reports, 2021 The inverse renormalization group is studied based on the image super-resolution using the deep convolutional neural networks. We consider the improved correlation configuration instead of spin configuration for the spin models, such as the two ...
Kenta Shiina +4 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source