Results 121 to 130 of about 64,923 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Collective Responsibility and Collective Obligations without Collective Agents

, 2020
It is commonplace to attribute obligations to φ or blameworthiness for φ-ing to groups even when no member has an obligation to φ or is individually blameworthy for not φ-ing.
Björnsson, Gunnar,
core  

CENTRAL COUNTERPARTIES ON ROMANIAN CAPITAL MARKET [PDF]

Challenges of the Knowledge Society
Capital markets refer to clearing as to the process of establishing „positions”, i.e., ownership of a particular security, like a stock or derivative, at a given time, including the calculation of net obligations, and ensuring that financial instruments,
Cristian GHEORGHE
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Peel Harvey Biosecurity Group Annual Report 2018/19

, 2019
2019 has been a great time for the team at the Peel Harvey Biosecurity Group (PHBG) achieving many things to help sustain the group into the future and ensure that people in the community are aware of their pest control obligations.
Peel Harvey Biosecurity Group
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Doing away with the case method: What could go wrong?

, 2019
In recent years there has been much discussion about the use and abuse of the ‘casebook’ method of teaching contract law. It is alleged that the casebook method is out-of-touch with legal practice and that contract law teaching should be more skills ...
Roberts, Marcus
core  

A Three-Pronged Approach to Human Rights Obligations of Non-State Armed Groups

, 2018
Chapter 6 proposes a three-pronged approach to possible human rights obligations of armed groups by distinguishing between (i) human rights obligations of groups exercising quasi-governmental authority in defined territory; (ii) human rights obligations ...
Tilman Rodenhäuser
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A vertex oriented approach to the equal remaining obligations rule for the minimum cost spanning tree problems

, 2009
In this paper, we consider spanning tree situations, where players want to be connected to a source as cheap as possible. These situations involve the construction of a spanning tree with the minimum cost as well as the allocation of the cost of this ...
Tijs, S.H., Ciftci, B.B.
core