Results 111 to 120 of about 64,923 (310)

Unspoken obligations: perspectives on post-trial responsibilities from Tanzanian research ethics committee and researchers

Global Bioethics
Introduction: Ethical considerations in clinical research extend beyond trial completion, emphasizing post-trial responsibilities to ensure participant well-being, particularly in resource-limited settings.
Rose Mwangi, Sabina Mtweve, Blandina T. Mmbaga, Rachel Manongi   +3 more
doaj   +1 more source

PLANTS FROM THE HABITAT DIRECTIVE – ANNEX IIb, PRESENTS IN ROMANIA [PDF]

Journal of Plant Development, 2007
In order to assist the Romanian Government in fulfilling their obligations required to become a full member of the European Union, the Dutch Agency for International Business and Cooperation (EVD) developed a special project, focused on Habitat Directive
SÂRBU ION, OPREA ADRIAN, SÂRBU ANCA
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Intergenerational ethics and climate change [PDF]

Global climate change has important implications for the way in which benefits and burdens will be distributed amongst present and future generations.
Page, Edward
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prediction of dialogue acts on the basis of the previous act

, 2007
En este trabajo se evalúa empíricamente el reconocimiento automático de actos de diálogo. Se usan datos provenientes de un corpus de diálogos con habla espontánea.
Coria Olguín, Sergio Rafael, Pineda Cortés, Luis Alberto   +1 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Africa’s Finance Ministers and Private Sector Group seek to rapidly resolve commercial debt service obligations together

, 2020
The United Nations Economic Commission for Africa (ECA) on Monday convened a meeting between African Finance Ministers, the Africa Private Sector Working Group and the African Union (AU) Special Envoy on COVID19 as the search continues for solutions to ...

core  

Obligations to Reduce Emissions: From the Oslo Principles to Enterprises

, 2017
The release of Greenhouse Gases (GHGs) by the activities of humans is a major contributor to current global climate change. A major environmental catastrophe caused by this climate change will be averted only if the emission of GHGs are drastically ...
Philip Sutherland
core   +1 more source