Results 91 to 100 of about 64,923 (310)
Auditor obligations in an evolving legal landscape\ud
, 2013 Purpose – \ud The purpose of this paper is to look at auditor obligations to their clients and potentially to third parties such as investors, with a focus on the quality of financial disclosure in an evolving legal framework.\ud \ud Design/methodology ...
Mack, Janet, Tarr, Julie-Anne
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Individual and Shared Obligations : In Defense of the Activist's Perspective
, 2021 We naturally attribute obligations to groups, and take such obligations to have consequences for the obligations of group members. The threat posed by anthropogenic climate change provides an urgent case. It seems that we, together, have an obligation to
Björnsson, Gunnar,
core
КавказологияThe article defines the role of debt obligations in the system of regulation of public relations among the Balkarian population of the Nalchik district of the Tersk region in the last third of the XIX – early XX century. For this purpose, the practice of
Azinat Zh. Baichekueva
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Kampala Convention and obligations armed groups
Forced Migration Review, 2011 The Kampala Convention imposes a number of obligations on armed groups in order to better protect IDPs; the challenge now is to encourage such groups to recognise these obligations....
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Equitable estoppel in New Zealand: Where are the limits?
, 2019 Over the last 30 years, the New Zealand courts have steadily expanded the boundaries of equitable estoppel. There is no longer a meaningful distinction between equitable and proprietary estoppel: instead they have been collapsed into a single doctrine ...
Roberts, Marcus
core
Study Regarding the Evolution of the Financial Balance in the Pharmaceutical Industry
Studies in Business and Economics, 2015 This article aims at analysing the financial balance within the global pharmaceutical industry, starting from the assumption that „In the pharmaceutical industry there is sufficient liquidity to cover payment obligations”. The analysed companies are part
Grigoroi Lilia +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source