Results 81 to 90 of about 64,923 (310)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Collective Obligations and the Moral Hi-Lo Game [PDF]
, 2023 Olle Blomberg and Björn Petersson (2023) argue that collective moral obligations, at least in some cases, are irreducibly collective. By this they mean the subject of the obligation is a group and their having a moral obligation collectively cannot be ...
Ludwig, Kirk
core +1 more source
International legal obligations of armed opposition groups in Syria
International Review of Law, 2015 Starting with peaceful protests of people demanding democratic reforms and fundamental rights from the regime in Damascus, the Syria crisis developed into a full-fledged civil war causing largescale death, injury, and displacement. During the first year of the crisis, violence in Syria was marked by the brutal crackdown of regime forces on protesters ...
openaire +5 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Global Poverty, Structural Injustice and Obligations to take Political Action [PDF]
, 2013 This work considers the moral obligations agents have in relation to global poverty. Utilising a practical ethics approach, it aims to provide an account of obligation that is explicitly political.
Kahn, Elizabeth
core
Collective responsibility and collective obligations without collective moral agents [PDF]
, 2020 It is commonplace to attribute obligations to φ or blameworthiness for φ-ing to groups even when no member has an obligation to φ or is individually blameworthy for not φ-ing.
Björnsson, Gunnar
core
Māori perspectives on sleep and aging
Frontiers in SleepIntroductionSleep is vital for health in older adulthood. Ethnic disparities have been noted with regards to sleep health. However, culturally appropriate approaches to sleep as a broader social experience are lacking.MethodsHere, sleep-related group ...
Rosemary Gibson +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source