Results 61 to 70 of about 64,923 (310)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The role of moral intention and moral obligation in predicting attitudes toward avoiding AIgiarism: A protection motivation theory perspective

Computers in Human Behavior Reports
Traditional methods of combating plagiarism have proven ineffective due to the dual use of AI chatbots to plagiarize and avoid detection. Therefore, there is a growing rationale to focus on moral responsibility towards protecting academic integrity. This
Ismail Mohamed Ali, Ibrahim Arpaci
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Collective obligations, commitments and individual obligations: a preliminary study [PDF]

, 2002
A collective obligation is an obligation directed to a group of agents so that the group, as a whole, is obliged to achieve a given task. The problem investigated here is to study the impact of collective obligations to individual obligations, i.e ...
Laurence Cholvy, Garion, Christophe, Cholvy, Laurence, Christophe Garion   +3 more
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

System-Level Legal Knowledge of Patients’ Rights and Related Obligations [PDF]

Interdisciplinary Description of Complex Systems
Patients’ rights are a fundamental component of ethical and legally compliant healthcare, with professionals bearing primary responsibility for their implementation.
Iva Lončarić Kelečić, Maroje Višić, Helena Konjevoda, Vesna Konjevoda   +3 more
doaj   +1 more source

A formal theory of group-level adaptation for obligate eusociality

Journal of Evolutionary Biology
Abstract Darwin argued that natural selection leads organisms to appear as if they are striving to maximize their fitness. This idea is readily recognized at the individual cell or body level, but such adaptive design may also manifest at some higher levels of biological organization.
Kalyani Z Twyman, Andy Gardner
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Principles on climate obligations of enterprises

, 2017
Climate change is the most important challenge humankind has ever faced. It is commonly accepted that greenhouse gas (GHG) emissions must be reduced at great pace and to a significant extent to keep global warming below 2 (or, preferably, 1.5) degrees ...
Expert Group on Climate Obligations of Enterprises
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source