Results 21 to 30 of about 2,169,177 (303)

Modulating the microenvironment during FVIII uptake influences the nature of FVIII-peptides presented by antigen-presenting cells

Frontiers in Immunology, 2022
Background and aimsHemophilia A is a severe bleeding disorder caused by the deficiency of functionally active coagulation factor VIII (FVIII). The induction of neutralizing anti-drug antibodies is a major complication in the treatment of hemophilia A ...
Christian Lubich, Christian Lubich, Katharina Nora Steinitz, Brigitte Hoelbl, Thomas Prenninger, Pauline Maria van Helden, Markus Weiller, Birgit Maria Reipert, Birgit Maria Reipert   +8 more
doaj   +1 more source

Pancreatic enzymes in the treatment of painful chronic pancreatitis with moderate exocrine insufficiency

Медицинский совет, 2013
The term chronic pancreatitis (CP) is used to denote a group of chronic diseases of the pancreas of various etiology, predominantly inflammatory, with several phases of progress, and characterized by focal, segmental or diffuse degenerative and ...
M. I. Shchyokina, M. S. Panchuk
doaj   +1 more source

Integrated Approach to the Construction of Geological Models Based on Facies Analysis

Georesursy
Using an integrated approach, 3D geological and hydrodynamic models were built using the results of facies analysis. A sedimentological description of the core was carried out with the interpretation of facies, the formation of which occurred in ...
O. S. Generalenko, I. V. Shelepov, O. E. Ermakova, I. V. Motorin, G. N. Vorobyova, D. D. Paramoshina   +5 more
doaj   +1 more source

Liver as the target organ: what we can do to help the patient

Медицинский совет, 2013
Liver diseases of various origin are a common cause of morbidity and mortality. The pathogenetic mechanism of hepatocyte damage consists in the destruction of the membrane structure in a certain way. It is recommended to use drugs exhibiting revitalizing
E. B. Grishchenko, M. I. Shchyokina
doaj   +1 more source

Lithological Structure and Oil and Gas Source Potential of the Chernoyarsk Horizon in the Central Part of the Rubezhinsky Trough (Based on Drilling Results)

Georesursy
The Chernoyarsk horizon of the Middle Devonian is one of the most poorly studied source rock in the south of the orenburg region. The data obtained from the results of drilling the first exploratory well on the territory of the Solnechnyj License area ...
V. A. Rybakova, A. P. Vilesov, V. A. Kozlova, N. Yu. Grebenkina, V. S. Ledenev, D. V. Solodov   +5 more
doaj   +1 more source

Case studies and operation features of transient multiphase flow in low-flow wells with multistage fracturing and extended horizontal wellbore operated with ESP in PSA mode

Petroleum Research
The article is dedicated to the analysis and modeling of the operation modes of low-flow wells with extended horizontal wellbore (HW) and multi-stage hydraulic fracturing (MHF) during artificial lift with an electric submersible pump (ESP).
T.S. Yushchenko, E.V. Demin, V.A. Ivanov, R.A. Khabibullin, A.V. Volkov   +4 more
doaj   +1 more source

Industrial application of heat- and mass balance model for fluid-bed granulation for technology transfer and design space exploration

International Journal of Pharmaceutics: X, 2019
This work demonstrates the application of state-of-the-art modeling techniques in pharmaceutical manufacturing for fluid bed granulation at varying scales to successfully predict process conditions and ultimately replace experiments during a technology ...
David R. Ochsenbein, Matthew Billups, Bingbing Hong, Elisabeth Schäfer, Alexander J. Marchut, Olav K. Lyngberg   +5 more
doaj   +1 more source

Harvesting systems for steep terrain in the Italian Alps: state of the art and future prospects [PDF]

, 2016
Steep slope forest operations in Central Europe and in particular in the Alps are strongly related to the adoption of the cable-based harvesting system, even if innovative ground-based harvesting system, even if innovative ground-based harvesting systems
Cavalli, Raffaele, Grigolato, Stefano, Mologni, Omar   +2 more
core   +1 more source

Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

BMC Gastroenterology, 2018
Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol.
Renger G. Tiessen, Ciara A. Kennedy, Bradley T. Keller, Nancy Levin, Lisette Acevedo, Bronislava Gedulin, Andre A. van Vliet, Alejandro Dorenbaum, Melissa Palmer   +8 more
doaj   +1 more source

Groups of Companies and Liability within the Group [PDF]

Journal of Forensic Accounting Profession, 2021
Abstract Groups of companies have existed ever since the early 20th century in the legal and economic terms. Over time, their concept was complemented, both in legislation and in the corporate practice. The issue of establishing and managing groups of companies is regulated by the corporate legislation.
openaire   +1 more source