Results 41 to 50 of about 167,375,017 (300)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Formulation of Strategic Plan for a Financial Technology Startup Company

International Journal of Academe and Industry Research, 2023
This study formulated a strategic plan for a financial technology start-up company in the Philippines. The business model involves selling airtime prepaid loads and mobile top-ups, channel and medium for various remittance and financial institutions, and
Angelo Efren G. Ngo
doaj   +1 more source

Antea Group Archeologie 2019/200

, 2020
In opdracht van J.A. Rodenburg B.V. heeft Antea Group in november 2019 een archeologisch booronderzoek uitgevoerd op een perceel nabij de Denariusstraat 19 te Oosterhout.
Koopmanschap, Dr. H.J.L.C. (Antea Group), Sophie, Drs. G. (Antea Group), Colijn, MA J.E. (Antea Group), Sophie, Drs. G (Antea Group)   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

About approaches to a universal distributed trusted registry to ensure confidentiality of system information

Безопасность информационных технологий, 2019
Currently, under the current international sanctions, the task of building a system of distributed registries with high transactional speed and using symmetric cryptographic algorithms, as well as providing minimal or controlled disclosure of data about ...
Natalya I. Kasperskaya, Vasily V. Kuzmenko, Rustem N. Khairetdinov, Andrey Yu. Shcherbakov   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Antea Group Archeologie 2020/23

, 2020
In februari 2020 heeft Antea Group in opdracht van EuroParcs een archeologisch onderzoek uitgevoerd voor het plangebied ‘Recreatiepark Henschotermeer Wouderberg’ te Woudenberg, gemeente Woudenberg.
Antea Group
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reflection of documents in the digital twin of the company and calculation of their impact on human behavior in the simulation model

E-Management, 2021
The formation and formation of the Industry 4.0 concept stimulated the discussion of the use of computer technology in various areas of economic activity and, in particular, in the automation of social systems management.
M. V. Samosudov
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source