Results 21 to 30 of about 265,588 (261)

Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

BMC Gastroenterology, 2018
Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol.
Renger G. Tiessen, Ciara A. Kennedy, Bradley T. Keller, Nancy Levin, Lisette Acevedo, Bronislava Gedulin, Andre A. van Vliet, Alejandro Dorenbaum, Melissa Palmer   +8 more
doaj   +1 more source

Optimization of a single-embryo transfer by using time-lapse microscopy in IVF and ICSI programs

Медицинский совет, 2020
Introduction. Due to refinements of assisted reproductive technology, the number of multiple pregnancies has increased substantially. Therefore, transfer of a single embryo, as opposed to multiple embryos, is a top-priority task in ART-based infertility ...
N. V. Saraeva, N. V. Spiridonova, M. T. Tugushev, O. V. Shurygina, A. I. Sinitsyna   +4 more
doaj   +1 more source

Group Company Liability [PDF]

European Business Organization Law Review, 2018
According to a universal bedrock principle of corporate law, corporations have separate legal personality and limited liability. These principles apply equally to corporate groups. Accordingly, a parent company is normally not liable for legal infractions and unpaid debts of its subsidiaries.
Petrin, M, Choudhury, B
openaire   +2 more sources

Lithological Structure and Oil and Gas Source Potential of the Chernoyarsk Horizon in the Central Part of the Rubezhinsky Trough (Based on Drilling Results)

Georesursy
The Chernoyarsk horizon of the Middle Devonian is one of the most poorly studied source rock in the south of the orenburg region. The data obtained from the results of drilling the first exploratory well on the territory of the Solnechnyj License area ...
V. A. Rybakova, A. P. Vilesov, V. A. Kozlova, N. Yu. Grebenkina, V. S. Ledenev, D. V. Solodov   +5 more
doaj   +1 more source

Industrial application of heat- and mass balance model for fluid-bed granulation for technology transfer and design space exploration

International Journal of Pharmaceutics: X, 2019
This work demonstrates the application of state-of-the-art modeling techniques in pharmaceutical manufacturing for fluid bed granulation at varying scales to successfully predict process conditions and ultimately replace experiments during a technology ...
David R. Ochsenbein, Matthew Billups, Bingbing Hong, Elisabeth Schäfer, Alexander J. Marchut, Olav K. Lyngberg   +5 more
doaj   +1 more source

Case studies and operation features of transient multiphase flow in low-flow wells with multistage fracturing and extended horizontal wellbore operated with ESP in PSA mode

Petroleum Research
The article is dedicated to the analysis and modeling of the operation modes of low-flow wells with extended horizontal wellbore (HW) and multi-stage hydraulic fracturing (MHF) during artificial lift with an electric submersible pump (ESP).
T.S. Yushchenko, E.V. Demin, V.A. Ivanov, R.A. Khabibullin, A.V. Volkov   +4 more
doaj   +1 more source

A Pharmacokinetic Bridging Study to Compare Systemic Exposure to Budesonide between Budesonide Oral Suspension and ENTOCORT EC in Healthy Individuals

Drugs in R&D, 2020
Background and Objectives Currently, there are no US FDA-approved therapies for eosinophilic esophagitis (EoE). Budesonide oral suspension (BOS; SHP621, TAK-721) is a viscous, muco-adherent, oral formulation of budesonide that is in phase III development
Ivy H. Song, Richard D. Finkelman, Lan Lan   +2 more
doaj   +1 more source

Development of an In Vitro Biopotency Assay for an AAV8 Hemophilia B Gene Therapy Vector Suitable for Clinical Product Release

Molecular Therapy: Methods & Clinical Development, 2020
Gene therapy product release requires reliable and consistent demonstration of biopotency. In hemophilia B vectors, this is usually determined in vivo by measuring the plasma levels of the expressed human factor IX (FIX) transgene product in FIX knockout
Johannes Lengler, Sogue Coulibaly, Bernadette Gruber, Reinhard Ilk, Josef Mayrhofer, Friedrich Scheiflinger, Werner Hoellriegl, Falko G. Falkner, Hanspeter Rottensteiner   +8 more
doaj   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

Adaptation of the performance control system of a technological piston hydrogen compressor to unstable operating conditions [PDF]

Омский научный вестник: Серия "Авиационно-ракетное и энергетическое машиностроение"
Issues related to possible problems of the feasibility of operating the existing system for regulating the performance of a technological piston hydrogen compressor at a large chemical production and the relevance of its modernization are considered ...
V. L. Yusha, M. A. Sutyaginskiy, Yu. A. Potapov, G. S. Russkikh   +3 more
doaj   +1 more source