Results 61 to 70 of about 2,178,211 (303)

Alirokumab in the practice of a multidisciplinary outpatient hospital: results of an open, noncomparative prospective study

Сеченовский вестник, 2020
Aim. Evaluation of efficacy and safety of alirocumab in patients with atherogenic dyslipidemia in real clinical practice.Materials and methods. Patients with atherogenic dyslipidemia and failure to achieve target lipid levels were included in a ...
A. O. Bueverov, P. O. Bogomolov, A. A. Kucherov, V. E. Syutkin   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

How Leading International Dairy Companies Adjusted to Changes in World Markets [PDF]

This Discussion Paper focuses on strategic adjustments made by leading international dairy firms in response to world market developments in the late 1990s and early 2000s.
Dobson, William D., Wilcox, Andrew
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Evaluation of white grain maize varieties for growth, yield and yield components

Journal of Agriculture and Natural Resources, 2021
Maize (Zea mays L.) is one of the most commonly cultivated crop after rice in Nepal. The present study was done to evaluate and recommend the best performing white maize genotypes in mid hill region of Nepal.
Arjun Bastola, Ankit Soti, Utshav Pandey, Mausami Rana, Manoj Kandel, Jiban Shrestha   +5 more
doaj  

RESEARCH ON OBTAINING AND USING MARKETING INFORMATION IN COMMERCE COMPANIES [PDF]

The present paper focuses on the issue of using marketing instruments (concepts, policies, strategies, research etc.) in commerce companies in Brasov.
Marius BALASESCU, Simona BALASESCU
core  

Determinants of cooperation with institutional partners and innovation - performance of Polish manufacturing enterprises. Research outcomes [PDF]

, 2013
The aim of this paper is to assess of the influence of institutional cooperation (with research institutes and universities) on the innovation performance of companies as well as determinants of such cooperation.
Lewandowska, Małgorzata Stefania
core