Results 61 to 70 of about 2,168,981 (303)

Idursulfase pharmacokinetics, cellular uptake, and pharmacodynamics: Effect of sialylation and manufacturing process

Engineering Reports, 2020
Recombinant iduronate‐2‐sulfatase (idursulfase) is available for the treatment of mucopolysaccharidosis II (MPS II). The effectiveness of this glycoprotein may depend on post‐translational modifications such as glycosylation and sialylation during ...
Antony R. Garcia, Justin Lamsa, David A. H. Whiteman, Joseph Muenzer   +3 more
doaj   +1 more source

Alirokumab in the practice of a multidisciplinary outpatient hospital: results of an open, noncomparative prospective study

Сеченовский вестник, 2020
Aim. Evaluation of efficacy and safety of alirocumab in patients with atherogenic dyslipidemia in real clinical practice.Materials and methods. Patients with atherogenic dyslipidemia and failure to achieve target lipid levels were included in a ...
A. O. Bueverov, P. O. Bogomolov, A. A. Kucherov, V. E. Syutkin   +3 more
doaj   +1 more source

Financial benchmarking of transportation companies in the New York Stock Exchange (NYSE) through data envelopment analysis (DEA) and visualization [PDF]

, 2006
In this paper, we present a benchmarking study of industrial transportation companies traded in the New York Stock Exchange (NYSE). There are two distinguishing aspects of our study: First, instead of using operational data for the input and the output ...
Ertek, Gurdal, Ertek, Gürdal, Kose, Ozlem, Köse, Özlem, Sen, Simay, Ulus, Firdevs, Şen, Simay   +6 more
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Customer population modelling with residence time structure [PDF]

, 2002
In many service industries, companies offer a variety of customer packages, with differing levels of service and associated charges. For example, in the case of cable companies, customers may choose to subscribe to different bundles of channels and may ...
Wilson, Eddie
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Evaluation of white grain maize varieties for growth, yield and yield components

Journal of Agriculture and Natural Resources, 2021
Maize (Zea mays L.) is one of the most commonly cultivated crop after rice in Nepal. The present study was done to evaluate and recommend the best performing white maize genotypes in mid hill region of Nepal.
Arjun Bastola, Ankit Soti, Utshav Pandey, Mausami Rana, Manoj Kandel, Jiban Shrestha   +5 more
doaj  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Going-Concern Opinions: Broadening the Expectations Gap [PDF]

, 2003
A rash of high-profile bankruptcies has led to a search for answers. Many hold auditors responsible for not detecting the potential for bankruptcy during the most recent audit.
Akers, Michael D., Giacomino, Don, Maher, Meredith A   +2 more
core   +1 more source