Results 71 to 80 of about 2,169,177 (303)

Idursulfase pharmacokinetics, cellular uptake, and pharmacodynamics: Effect of sialylation and manufacturing process

open access: yesEngineering Reports, 2020
Recombinant iduronate‐2‐sulfatase (idursulfase) is available for the treatment of mucopolysaccharidosis II (MPS II). The effectiveness of this glycoprotein may depend on post‐translational modifications such as glycosylation and sialylation during ...
Antony R. Garcia   +3 more
doaj   +1 more source

Alirokumab in the practice of a multidisciplinary outpatient hospital: results of an open, noncomparative prospective study

open access: yesСеченовский вестник, 2020
Aim. Evaluation of efficacy and safety of alirocumab in patients with atherogenic dyslipidemia in real clinical practice.Materials and methods. Patients with atherogenic dyslipidemia and failure to achieve target lipid levels were included in a ...
A. O. Bueverov   +3 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

RESEARCH ON OBTAINING AND USING MARKETING INFORMATION IN COMMERCE COMPANIES [PDF]

open access: yes
The present paper focuses on the issue of using marketing instruments (concepts, policies, strategies, research etc.) in commerce companies in Brasov.
Marius BALASESCU, Simona BALASESCU
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Neuromuscular blockade in anaesthesia for maxillofacial cancer surgery: specifics, advantages, challenges and solutions (literary review)

open access: yesОпухоли головы и шеи
This review discusses the problem of safe, controlled myoplegia during anesthesia in patients with tumors of the maxillofacial area. Anatomical features of this category of patients affecting the permeability of the upper respiratory tract during ...
T. E. Selina   +2 more
doaj   +1 more source

Evaluation of white grain maize varieties for growth, yield and yield components

open access: yesJournal of Agriculture and Natural Resources, 2021
Maize (Zea mays L.) is one of the most commonly cultivated crop after rice in Nepal. The present study was done to evaluate and recommend the best performing white maize genotypes in mid hill region of Nepal.
Arjun Bastola   +5 more
doaj  

A Merton Model Approach to Assessing the Default Risk of UK Public Companies [PDF]

open access: yes
This paper shows how a Merton-model approach can be used to develop measures of the probability of failure of quoted UK companies. Probability estimates are constructed for a group of failed companies and their properties as leading indicators of failure
Garry Young, Tudela, Merxe
core  

Going-Concern Opinions: Broadening the Expectations Gap [PDF]

open access: yes, 2003
A rash of high-profile bankruptcies has led to a search for answers. Many hold auditors responsible for not detecting the potential for bankruptcy during the most recent audit.
Akers, Michael D.   +2 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

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