Results 71 to 80 of about 188,766 (316)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Lie group analysis, solitary wave solutions and conservation laws of Schamel Burger’s equation

Partial Differential Equations in Applied Mathematics
This paper presents a Lie group analysis of the Schamel Burger’s equation, notable for producing shock-type traveling waves in distinctive physical contexts.
Naseem Abbas, Amjad Hussain, Firdous Bibi   +2 more
doaj   +1 more source

Isometries in finite groups of Lie type

Journal of Algebra, 1973
Publisher Summary This chapter discusses the isometries in finite groups of lie type. Let G be a connected semisimple linear algebraic group and σ a surjective endomorphism of G, such that the group of fixed points G σ = G is finite. Then G is a finite group of Lie type. Let T be a maximal torus of G fixed by σ and T = T, H = N G (T), H/T = W. Then T
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Coordinate-free Lie-group-based modeling and simulation of a submersible vehicle

AIMS Mathematics
Submersible vehicles may be regarded as complex systems because of their complex interaction with the surrounding fluid. This paper presents a mathematical model of a submersible vehicle formulated in a coordinate-free manner through the language of Lie ...
Simone Fiori
doaj   +1 more source

Poisson-Lie analogues of spin Sutherland models

Nuclear Physics B, 2019
We present generalizations of the well-known trigonometric spin Sutherland models, which were derived by Hamiltonian reduction of ‘free motion’ on cotangent bundles of compact simple Lie groups based on the conjugation action.
L. Fehér
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

The essential $l$-dimension of finite groups of Lie type, $l \neq 2$ [PDF]

, 2022
Hannah Knight
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source