Results 101 to 110 of about 2,156,473 (283)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Rings all of whose additive group endomorphisms are left multiplications
International Journal of Mathematics and Mathematical Sciences, 1984 Motivated by Cauchy's functional equation f(x+y)=f(x)+f(y), we study in §1 special rings, namely, rings for which every endomorphism f of their additive group is of the form f(x)≡ax. In §2 we generalize to R algebras (R a fixed commutative ring) and give
Michael I. Rosen, Oved shisha
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Journal of Open Innovation: Technology, Market and ComplexityThe purpose of this study is to evaluate Exogenous Risk Factors (ERFs) affecting Key Performance Indicators (KPIs) in automotive supply chains, aiming to enhance resilience against global disruptions.
Ishansh Gupta +3 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Scientific ReportsLateritic soils, also known as red soils, are prone to actions of external environment such as wetting and drying processes and their cycling. However, in the practice of pavement design in red soil regions, there lacks experimental studies and ...
Sen Deng +7 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
On Orbits of the Ring Zmn under Action of the Group SL(m, Zn)
Acta Polytechnica, 2005 We consider the action of the finite matrix group SL(m,Zn ) on the ring Zmn. We determine orbits of this action for n arbitrary natural number. It is a generalization of the task which was studied by A. A. Kirillov for m = 2 and n prime number.
P. Novotný, J. Hrivnák
doaj
Detecting underdetermination in parameterized quantum circuits
Machine Learning: Science and TechnologyA central question in machine learning is how reliable the predictions of a trained model are. Reliability includes the identification of instances for which a model is likely not to be trusted based on an analysis of the learning system itself.
Marie Kempkes +3 more
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