Results 61 to 70 of about 632,128 (218)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Finite subgroups of group rings: a survey [PDF]
Advances in Group Theory and Applications, 2019 Leo Margolis, Ángel del Río
doaj +1 more source
Research on Operation Trajectory Tracking Control of Loader Working Mechanisms
MachinesAutonomous shovel digging of loaders is the key technology to realise automation and intelligent operation. The effective tracking control for the target operation trajectory is one of its core parts.
Guodong Liang +7 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Astrophysical Journal LettersWe report the results of first ever spectropolarimetric analyses of the Galactic ultraluminous X-ray pulsar Swift J0243.6+6124 during the 2023 outburst using quasi-simultaneous IXPE, NICER, and NuSTAR observations.
Seshadri Majumder +4 more
doaj +1 more source
Randomized Modality Mixing with Patchwise RBF Networks for Robust Multimodal Pain Recognition
ComputersPain recognition based on multimodal physiological signals remains a challenge, not only because of the limited training data, but also due to the varying responses of individuals.
Mehmet Erdal +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Journal of Advanced Joining ProcessesWelding thin steel sheets in industrial applications is difficult because joint gaps occur during the process, which can lead to weld interruptions. Such welds are considered a reject and in order to avoid the weld to interrupt it is crucial to hinder ...
Dominik Walther +6 more
doaj +1 more source