Results 91 to 100 of about 9,527,915 (298)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The structure of balanced rings [PDF]
Dlab V, Ringel CM. The structure of balanced rings. Proceedings of the London Mathematical Society.
Dlab, Vlastimil, Ringel, Claus Michael
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Public Key Protocols from Twisted-Skew Group Rings
This article studies some algebraic structures known as twisted-skew group rings in the context of public key cryptography. We first present some background related to these structures to then specifically introduce particular twisted-skew group rings ...
Javier de la Cruz +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Symmetric Units and Group Identities in Group Algebras [PDF]
We describe those group algebras over fields of characteristic different from 2 whose units symmetric with respect to the classical involution, satisfy some group ...
Bódi, Viktor, Bovdi, Victor
core +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Line Scan Camera Calibration Based on Space Rings Group
In addition to the accuracy requirements, the calibration of the line scan camera (LSC) should also have strong operability and portability. This paper presents a low-cost high-reliability LSC calibration method.
Menghui Niu +4 more
doaj +1 more source
An associative ring \(R\) with identity is called left morphic if for every element \(a\in R\) there exists \(b\in R\) such that \(l_R(a)=Rb\) and \(l_R(b)=Ra\), where \(l_R(a)\) denotes the left annihilator of \(a\) in \(R\). The ring \(R\) is said to be strongly left morphic if every matrix ring \(M_n(R)\) is left morphic [\textit{W. K.
Chen, Jianlong +2 more
openaire +2 more sources

